Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC1419 Volasertib
0.00031623
PLK
Cell cycle
 1.3365 0.00331
MDA-MB-134-VI PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.3419 -0.00121
MDA-MB-134-VI Luminespib
0.0001
HSP90
Misc
 1.3453 -0.00808
MDA-MB-134-VI Cabozantinib
0.001
VEGFR2/MET
RTK
 1.3562 -0.00502
CAL-85-1 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.3608 -0.00028
MDA-MB-134-VI Neratinib
0.001
EGFR/HER2
RTK
 1.3618 -0.00624
MDA-MB-134-VI Cabozantinib
1.0
VEGFR2/MET
RTK
 1.3646 -0.00006
HCC70 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.3706 -0.00299
PDXHCI002 Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 1.3716 -0.03537
T47D AZD7762
0.01
CHK1/2
Cell cycle
 1.3830 -0.00136
MDA-MB-134-VI Dasatinib
0.01
BCR/ABL
MAPK/nRTK
 1.3853 0.00770
MDA-MB-134-VI Vorinostat
0.1
HDAC
Misc
 1.3902 0.00733
MDA-MB-134-VI Vorinostat
0.031623
HDAC
Misc
 1.4016 0.00246
MDA-MB-134-VI Saracatinib
10.0
SRC
MAPK/nRTK
 1.4045 0.03093
HCC1428 Cisplatin
0.01
Chemo
Chemotherapy
 1.4076 -0.00053
PDX1328 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.4111 0.00161
PDXHCI002 INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 1.4120 -0.03534
MDA-MB-134-VI Volasertib
0.00031623
PLK
Cell cycle
 1.4141 0.00230
MDA-MB-134-VI Neratinib
0.01
EGFR/HER2
RTK
 1.4151 -0.01219
MDA-MB-134-VI AZD7762
0.001
CHK1/2
Cell cycle
 1.4161 -0.00132
HCC70 Ceritinib
0.001
ALK
RTK
 1.4221 0.00355
PDXHCI002 Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 1.4354 -0.04922
MDA-MB-134-VI Saracatinib
0.0031623
SRC
MAPK/nRTK
 1.4491 0.00939
MDA-MB-134-VI Luminespib
0.001
HSP90
Misc
 1.4508 -0.01106
MDA-MB-134-VI AZD7762
0.01
CHK1/2
Cell cycle
 1.4630 0.02565