Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
T47D Everolimus
0.1
mTOR1
PI3K/mTOR
 0.4198 0.02159
T47D Everolimus
10.0
mTOR1
PI3K/mTOR
 0.2975 0.02128
T47D INK-128
0.031623
mTORC1/2
PI3K/mTOR
 0.0771 0.02991
T47D Everolimus
3.1623
mTOR1
PI3K/mTOR
 0.3515 0.01517
T47D INK-128
0.01
mTORC1/2
PI3K/mTOR
 0.2753 0.01646
T47D INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 1.0271 0.00098
T47D INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.9201 -0.00207
T47D INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 0.6751 0.00849
T47D Topotecan
3.1623
Topo I
Chemotherapy
 -0.1971 0.22591
T47D Etoposide
0.01
Topo II
Chemotherapy
 0.9163 -0.00041
T47D Taxol
0.0001
Chemo
Chemotherapy
 0.9933 0.01216
T47D Topotecan
0.031667
Topo I
Chemotherapy
 -0.0553 0.08658
T47D Taxol
0.01
Chemo
Chemotherapy
 0.0121 0.42909
T47D Cisplatin
0.01
Chemo
Chemotherapy
 0.9732 -0.00029
T47D Doxorubicin
0.1
Chemo
Chemotherapy
 -0.1199 0.11043
T47D Cisplatin
1.0
Chemo
Chemotherapy
 0.7136 0.00756
T47D Volasertib
0.00031623
PLK
Cell cycle
 1.1177 -0.00040
T47D Cisplatin
0.031667
Chemo
Chemotherapy
 1.0050 -0.00066
T47D Dinaciclib
0.01
pan CDK
Cell cycle
 1.0605 0.00600
T47D Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.1896 0.14363
T47D Dinaciclib
0.1
pan CDK
Cell cycle
 -0.1265 0.09974
T47D Volasertib
0.031623
PLK
Cell cycle
 0.5177 0.04885
T47D Palbociclib
0.01
CDK4/6
Cell cycle
 0.7784 0.00080
T47D AZD7762
1.0
CHK1/2
Cell cycle
 0.9057 0.01473
T47D Palbociclib
1.0
CDK4/6
Cell cycle
 0.1166 0.01548