Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
CAL-120 Palbociclib
0.31623
CDK4/6
Cell cycle
 0.7403 0.00544
CAL-120 Palbociclib
1.0
CDK4/6
Cell cycle
 0.7490 0.00656
CAL-120 Palbociclib
3.1623
CDK4/6
Cell cycle
 0.6687 0.00876
CAL-120 AZD7762
0.031623
CHK1/2
Cell cycle
 1.0537 0.04293
CAL-120 Volasertib
0.001
PLK
Cell cycle
 0.8155 0.03104
CAL-120 Palbociclib
0.0031623
CDK4/6
Cell cycle
 0.9914 -0.00056
CAL-120 Palbociclib
0.001
CDK4/6
Cell cycle
 1.0177 -0.00388
CAL-120 Palbociclib
0.01
CDK4/6
Cell cycle
 0.9405 -0.00778
CAL-120 Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.1408 0.25307
CAL-120 Abemaciclib
3.1623
CDK4/6
Cell cycle
 -0.0499 0.25033
CAL-120 Palbociclib
0.00031623
CDK4/6
Cell cycle
 1.0223 -0.00139
CAL-120 Palbociclib
0.031623
CDK4/6
Cell cycle
 0.8155 -0.00117
CAL-120 Abemaciclib
0.1
CDK4/6
Cell cycle
 0.6137 0.03921
CAL-120 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.6589 0.01241
CAL-120 Abemaciclib
0.31623
CDK4/6
Cell cycle
 0.6078 0.06270
CAL-120 Abemaciclib
0.001
CDK4/6
Cell cycle
 0.9255 -0.00231
CAL-120 Abemaciclib
0.0031623
CDK4/6
Cell cycle
 0.8593 -0.00223
CAL-120 Abemaciclib
0.01
CDK4/6
Cell cycle
 0.7275 0.00591
CAL-120 Abemaciclib
1.0
CDK4/6
Cell cycle
 0.3666 0.14489
CAL-120 Palbociclib
0.1
CDK4/6
Cell cycle
 0.7627 0.00467
CAL-120 Volasertib
0.0031623
PLK
Cell cycle
 0.2210 0.30234
CAL-120 Volasertib
0.01
PLK
Cell cycle
 -0.0324 0.45340
CAL-120 Volasertib
0.031623
PLK
Cell cycle
 -0.0473 0.44272
CAL-120 Bleomycin
0.0010833
Radiation
Misc
 0.9792 0.00323
CAL-120 Olaparib
10.0
PARP
Misc
 0.2688 0.10465