Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
BT-20 Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.0258 -0.00375
BT-20 Dinaciclib
0.01
pan CDK
Cell cycle
 0.9207 0.01310
BT-20 Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.2318 0.45734
BT-20 Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.6706 0.80415
BT-20 Dinaciclib
1.0
pan CDK
Cell cycle
 -0.6979 0.82310
BT-20 Abemaciclib
0.001
CDK4/6
Cell cycle
 0.9370 -0.00149
BT-20 Abemaciclib
0.0031623
CDK4/6
Cell cycle
 0.8833 -0.00527
BT-20 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.4936 -0.00426
BT-20 Abemaciclib
0.1
CDK4/6
Cell cycle
 0.3565 0.00950
BT-20 Abemaciclib
3.1623
CDK4/6
Cell cycle
 0.1622 0.01068
BT-20 Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.2160 0.37259
BT-20 Palbociclib
0.001
CDK4/6
Cell cycle
 1.0987 -0.00539
BT-20 Palbociclib
0.0031623
CDK4/6
Cell cycle
 0.9966 0.00011
BT-20 Palbociclib
0.31623
CDK4/6
Cell cycle
 0.2359 0.04751
BT-20 Palbociclib
1.0
CDK4/6
Cell cycle
 0.2044 0.04646
BT-20 AZD7762
0.001
CHK1/2
Cell cycle
 1.1198 -0.00253
BT-20 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.2431 -0.00726
BT-20 AZD7762
0.1
CHK1/2
Cell cycle
 1.1714 0.04490
BT-20 AZD7762
0.31623
CHK1/2
Cell cycle
 0.9454 0.07692
BT-20 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.1525 0.50057
BT-20 AZD7762
10.0
CHK1/2
Cell cycle
 -0.5785 0.71162
BT-20 Volasertib
0.01
PLK
Cell cycle
 0.0133 0.34529
BT-20 Volasertib
0.031623
PLK
Cell cycle
 -0.4356 0.63889
BT-20 Cisplatin
0.1
Chemo
Chemotherapy
 0.9474 0.00664
BT-20 Cisplatin
0.031667
Chemo
Chemotherapy
 1.0207 -0.00542