Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
---|---|---|---|---|---|---|
BT-20 | Dinaciclib | 0.0031623 | pan CDK | Cell cycle | 1.1052 | -0.01052 |
BT-20 | Dinaciclib | 0.031623 | pan CDK | Cell cycle | -0.2318 | 0.45734 |
BT-20 | Dinaciclib | 0.1 | pan CDK | Cell cycle | -0.6475 | 0.78890 |
BT-20 | Cisplatin | 0.0033333 | Chemo | Chemotherapy | 0.9228 | 0.00083 |
BT-20 | Cisplatin | 0.01 | Chemo | Chemotherapy | 0.9290 | 0.00291 |
BT-20 | Cisplatin | 0.1 | Chemo | Chemotherapy | 0.9474 | 0.00664 |
BT-20 | Cisplatin | 0.31623 | Chemo | Chemotherapy | 0.7633 | 0.01654 |
BT-20 | Cisplatin | 10.0 | Chemo | Chemotherapy | -0.3367 | 0.52833 |
BT-20 | Doxorubicin | 0.00031623 | Chemo | Chemotherapy | 0.9030 | -0.00402 |
BT-20 | Doxorubicin | 0.0031623 | Chemo | Chemotherapy | 0.8826 | 0.01682 |
BT-20 | Doxorubicin | 0.01 | Chemo | Chemotherapy | 0.4333 | 0.12869 |
BT-20 | Taxol | 0.0001 | Chemo | Chemotherapy | 0.8501 | 0.01100 |
BT-20 | Taxol | 0.00031623 | Chemo | Chemotherapy | 1.0128 | 0.00568 |
BT-20 | Taxol | 0.0031623 | Chemo | Chemotherapy | 0.1531 | 0.33718 |
BT-20 | Taxol | 0.01 | Chemo | Chemotherapy | -0.4404 | 0.67612 |
BT-20 | Taxol | 0.31623 | Chemo | Chemotherapy | -0.5527 | 0.73180 |
BT-20 | Taxol | 1.0 | Chemo | Chemotherapy | -0.5760 | 0.75435 |
BT-20 | Topotecan | 0.0033333 | Topo I | Chemotherapy | 0.8298 | 0.01267 |
BT-20 | Topotecan | 0.01 | Topo I | Chemotherapy | 0.5944 | 0.03501 |
BT-20 | Topotecan | 1.0 | Topo I | Chemotherapy | -0.5883 | 0.73829 |
BT-20 | Topotecan | 3.1623 | Topo I | Chemotherapy | -0.6410 | 0.75823 |
BT-20 | Etoposide | 0.0010833 | Topo II | Chemotherapy | 1.0323 | -0.00511 |
BT-20 | Etoposide | 0.0033333 | Topo II | Chemotherapy | 0.9830 | -0.00083 |
BT-20 | Cabozantinib | 0.01 | VEGFR2/MET | RTK | 1.0367 | 0.00057 |
BT-20 | Cabozantinib | 0.0031623 | VEGFR2/MET | RTK | 0.9808 | -0.00257 |