Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
T47D Dinaciclib
0.00031623
pan CDK
Cell cycle
 0.9825 0.00122
T47D Dinaciclib
0.01
pan CDK
Cell cycle
 1.0605 0.00600
T47D Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.0592 0.05833
T47D Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.1896 0.14363
T47D Dinaciclib
1.0
pan CDK
Cell cycle
 -0.2109 0.12913
T47D Abemaciclib
0.001
CDK4/6
Cell cycle
 0.8683 -0.00073
T47D Abemaciclib
0.0031623
CDK4/6
Cell cycle
 0.6048 0.00282
T47D Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.1058 0.01541
T47D Abemaciclib
0.1
CDK4/6
Cell cycle
 0.1609 0.00818
T47D Abemaciclib
3.1623
CDK4/6
Cell cycle
 0.0494 0.06623
T47D Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.0412 0.10529
T47D Palbociclib
0.001
CDK4/6
Cell cycle
 1.0459 -0.00050
T47D Palbociclib
0.0031623
CDK4/6
Cell cycle
 1.0099 0.00184
T47D Palbociclib
0.31623
CDK4/6
Cell cycle
 0.1804 0.01826
T47D Palbociclib
1.0
CDK4/6
Cell cycle
 0.1166 0.01548
T47D AZD7762
0.001
CHK1/2
Cell cycle
 1.2145 -0.00469
T47D AZD7762
0.0031623
CHK1/2
Cell cycle
 1.2355 0.00015
T47D AZD7762
0.1
CHK1/2
Cell cycle
 1.2980 0.00257
T47D AZD7762
0.31623
CHK1/2
Cell cycle
 1.1810 0.00498
T47D AZD7762
3.1623
CHK1/2
Cell cycle
 0.2905 0.06193
T47D AZD7762
10.0
CHK1/2
Cell cycle
 -0.0573 0.09637
T47D Volasertib
0.01
PLK
Cell cycle
 0.8485 0.00521
T47D Volasertib
0.031623
PLK
Cell cycle
 0.5177 0.04885
T47D Cisplatin
0.1
Chemo
Chemotherapy
 0.9180 -0.00007
T47D Cisplatin
0.031667
Chemo
Chemotherapy
 1.0050 -0.00066