Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM159PT Dasatinib
1.0
BCR/ABL
MAPK/nRTK
 0.6437 0.00906
SUM159PT Dasatinib
3.1623
BCR/ABL
MAPK/nRTK
 0.6420 0.01044
SUM159PT Dasatinib
10.0
BCR/ABL
MAPK/nRTK
 0.5642 0.00623
SUM159PT Trametinib
0.0001
MEK
MAPK/nRTK
 0.9717 -0.00065
SUM159PT Trametinib
0.00031623
MEK
MAPK/nRTK
 0.9210 0.00023
SUM159PT Trametinib
0.001
MEK
MAPK/nRTK
 0.7877 -0.00422
SUM159PT Trametinib
0.0031623
MEK
MAPK/nRTK
 0.5799 0.00011
SUM159PT Trametinib
0.01
MEK
MAPK/nRTK
 0.4263 0.00436
SUM159PT Trametinib
0.031623
MEK
MAPK/nRTK
 0.3570 0.00616
SUM159PT Trametinib
0.1
MEK
MAPK/nRTK
 0.3210 0.00835
SUM159PT Trametinib
0.31623
MEK
MAPK/nRTK
 0.2910 0.00948
SUM159PT Trametinib
1.0
MEK
MAPK/nRTK
 0.2792 0.01143
SUM159PT Saracatinib
0.001
SRC
MAPK/nRTK
 1.0039 0.00597
SUM159PT Saracatinib
0.0031623
SRC
MAPK/nRTK
 0.9948 0.00237
SUM159PT Saracatinib
0.01
SRC
MAPK/nRTK
 0.9975 0.00299
SUM159PT Saracatinib
0.031623
SRC
MAPK/nRTK
 0.9951 0.00178
SUM159PT Saracatinib
0.1
SRC
MAPK/nRTK
 0.9933 0.00078
SUM159PT Saracatinib
0.31623
SRC
MAPK/nRTK
 0.9740 -0.00441
SUM159PT Saracatinib
1.0
SRC
MAPK/nRTK
 0.9048 -0.00737
SUM159PT Saracatinib
3.1623
SRC
MAPK/nRTK
 0.7780 -0.00871
SUM159PT Saracatinib
10.0
SRC
MAPK/nRTK
 0.5624 -0.00363
SUM159PT ABT-737
0.001
Bcl2/XL
Misc
 1.0121 0.00112
SUM159PT ABT-737
0.0031623
Bcl2/XL
Misc
 1.0081 0.00401
SUM159PT ABT-737
0.01
Bcl2/XL
Misc
 0.9958 0.00624
SUM159PT ABT-737
0.031623
Bcl2/XL
Misc
 1.0104 0.00492