Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HME1 Abemaciclib
10.0
CDK4/6
Cell cycle
 0.0156 0.11315
HME1 Palbociclib
0.00031623
CDK4/6
Cell cycle
 1.0311 -0.00246
HME1 Palbociclib
0.001
CDK4/6
Cell cycle
 1.0657 0.00072
HME1 Palbociclib
0.0031623
CDK4/6
Cell cycle
 1.0263 -0.00213
HME1 Palbociclib
0.01
CDK4/6
Cell cycle
 0.9519 -0.00073
HME1 Palbociclib
0.031623
CDK4/6
Cell cycle
 0.7940 0.00085
HME1 Palbociclib
0.1
CDK4/6
Cell cycle
 0.6353 0.02066
HME1 Palbociclib
0.31623
CDK4/6
Cell cycle
 0.4626 0.01438
HME1 Palbociclib
1.0
CDK4/6
Cell cycle
 0.3466 0.02537
HME1 Palbociclib
3.1623
CDK4/6
Cell cycle
 0.2572 0.04327
HME1 AZD7762
0.001
CHK1/2
Cell cycle
 1.0021 0.00329
HME1 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.1055 0.00093
HME1 AZD7762
0.01
CHK1/2
Cell cycle
 1.1707 0.00660
HME1 AZD7762
0.031623
CHK1/2
Cell cycle
 1.1018 0.04648
HME1 AZD7762
0.1
CHK1/2
Cell cycle
 0.7117 0.14865
HME1 AZD7762
0.31623
CHK1/2
Cell cycle
 0.3461 0.24737
HME1 AZD7762
1.0
CHK1/2
Cell cycle
 0.0390 0.36023
HME1 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.2195 0.46623
HME1 AZD7762
10.0
CHK1/2
Cell cycle
 -0.4780 0.75448
HME1 Volasertib
0.0001
PLK
Cell cycle
 1.0287 0.00014
HME1 Volasertib
0.00031623
PLK
Cell cycle
 1.0634 -0.00048
HME1 Volasertib
0.001
PLK
Cell cycle
 1.1101 0.00295
HME1 Volasertib
0.0031623
PLK
Cell cycle
 1.0637 0.00331
HME1 Volasertib
0.01
PLK
Cell cycle
 0.8786 0.01365
HME1 Volasertib
0.031623
PLK
Cell cycle
 0.0816 0.20348