Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC1428 PF-4708671
0.31623
p70S6K
PI3K/mTOR
 0.9542 -0.00257
HCC1428 PF-4708671
1.0
p70S6K
PI3K/mTOR
 0.9540 -0.00529
HCC1428 PF-4708671
3.1623
p70S6K
PI3K/mTOR
 0.9654 -0.00371
HCC1428 PF-4708671
10.0
p70S6K
PI3K/mTOR
 0.8643 0.00765
HCC1428 Buparlisib
0.001
pan PI3K
PI3K/mTOR
 0.9851 0.00583
HCC1428 Buparlisib
0.0031623
pan PI3K
PI3K/mTOR
 1.0879 -0.00187
HCC1428 Buparlisib
0.01
pan PI3K
PI3K/mTOR
 0.9271 0.00223
HCC1428 Buparlisib
0.031623
pan PI3K
PI3K/mTOR
 1.0830 0.00439
HCC1428 Buparlisib
0.1
pan PI3K
PI3K/mTOR
 0.9067 0.00447
HCC1428 Buparlisib
0.31623
pan PI3K
PI3K/mTOR
 0.8370 0.01706
HCC1428 Buparlisib
1.0
pan PI3K
PI3K/mTOR
 0.2885 0.21685
HCC1428 Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 -0.2389 0.41545
HCC1428 Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.2646 0.31371
HCC1428 Pictilisib
0.001
pan PI3K
PI3K/mTOR
 0.8823 0.00296
HCC1428 Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9836 -0.00029
HCC1428 Pictilisib
0.01
pan PI3K
PI3K/mTOR
 1.0472 0.00401
HCC1428 Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 0.9306 0.00713
HCC1428 Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.9920 0.00598
HCC1428 Pictilisib
0.31623
pan PI3K
PI3K/mTOR
 0.9694 0.00413
HCC1428 Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.7769 0.01693
HCC1428 Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 0.8268 0.01835
HCC1428 Pictilisib
10.0
pan PI3K
PI3K/mTOR
 0.1916 0.21997
HCC1428 Ceritinib
0.001
ALK
RTK
 0.9904 -0.00448
HCC1428 Ceritinib
0.0031623
ALK
RTK
 1.0875 -0.00443
HCC1428 Ceritinib
0.01
ALK
RTK
 1.0651 -0.00478