Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
T47D Trametinib
0.001
MEK
MAPK/nRTK
 1.0111 -0.00010
T47D Trametinib
0.0031623
MEK
MAPK/nRTK
 0.8172 0.00321
T47D Trametinib
0.01
MEK
MAPK/nRTK
 0.7542 0.00095
T47D Trametinib
0.031623
MEK
MAPK/nRTK
 0.6763 0.00326
T47D Trametinib
0.1
MEK
MAPK/nRTK
 0.6548 0.00883
T47D Trametinib
0.31623
MEK
MAPK/nRTK
 0.6842 0.00513
T47D Trametinib
1.0
MEK
MAPK/nRTK
 0.5801 0.00841
T47D Saracatinib
0.001
SRC
MAPK/nRTK
 0.9981 0.00265
T47D Saracatinib
0.0031623
SRC
MAPK/nRTK
 1.0569 -0.00057
T47D Saracatinib
0.01
SRC
MAPK/nRTK
 1.0350 -0.00053
T47D Saracatinib
0.031623
SRC
MAPK/nRTK
 0.9311 0.00148
T47D Saracatinib
0.1
SRC
MAPK/nRTK
 0.8660 0.00343
T47D Saracatinib
0.31623
SRC
MAPK/nRTK
 0.8357 0.00656
T47D Saracatinib
1.0
SRC
MAPK/nRTK
 0.6561 0.01083
T47D Saracatinib
3.1623
SRC
MAPK/nRTK
 0.5551 0.01802
T47D Saracatinib
10.0
SRC
MAPK/nRTK
 0.3892 0.03602
T47D ABT-737
0.001
Bcl2/XL
Misc
 1.0701 0.00004
T47D ABT-737
0.0031623
Bcl2/XL
Misc
 1.0789 -0.00066
T47D ABT-737
0.01
Bcl2/XL
Misc
 1.0560 0.00089
T47D ABT-737
0.031623
Bcl2/XL
Misc
 1.0432 -0.00060
T47D ABT-737
0.1
Bcl2/XL
Misc
 1.0484 -0.00093
T47D ABT-737
0.31623
Bcl2/XL
Misc
 1.1459 0.00138
T47D ABT-737
1.0
Bcl2/XL
Misc
 0.9866 0.00757
T47D ABT-737
3.1623
Bcl2/XL
Misc
 0.9441 0.01508
T47D ABT-737
10.0
Bcl2/XL
Misc
 0.5888 0.05311