Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF 10A Palbociclib
0.031623
CDK4/6
Cell cycle
 0.8531 -0.00692
MCF 10A Palbociclib
0.1
CDK4/6
Cell cycle
 0.7516 -0.00845
MCF 10A Palbociclib
0.31623
CDK4/6
Cell cycle
 0.6631 -0.00840
MCF 10A Palbociclib
1.0
CDK4/6
Cell cycle
 0.5753 -0.00773
MCF 10A Palbociclib
3.1623
CDK4/6
Cell cycle
 0.4544 -0.00579
MCF 10A AZD7762
0.001
CHK1/2
Cell cycle
 1.0181 0.00138
MCF 10A AZD7762
0.0031623
CHK1/2
Cell cycle
 1.0237 0.00162
MCF 10A AZD7762
0.01
CHK1/2
Cell cycle
 1.0189 -0.00002
MCF 10A AZD7762
0.031623
CHK1/2
Cell cycle
 0.9948 0.00510
MCF 10A AZD7762
0.1
CHK1/2
Cell cycle
 0.9241 0.00588
MCF 10A AZD7762
0.31623
CHK1/2
Cell cycle
 0.8435 0.01423
MCF 10A AZD7762
1.0
CHK1/2
Cell cycle
 0.6678 0.03482
MCF 10A AZD7762
3.1623
CHK1/2
Cell cycle
 0.3119 0.12364
MCF 10A AZD7762
10.0
CHK1/2
Cell cycle
 -0.1800 0.53481
MCF 10A Volasertib
0.0001
PLK
Cell cycle
 1.0023 0.00027
MCF 10A Volasertib
0.00031623
PLK
Cell cycle
 1.0058 0.00024
MCF 10A Volasertib
0.001
PLK
Cell cycle
 1.0047 -0.00109
MCF 10A Volasertib
0.0031623
PLK
Cell cycle
 0.9995 0.00187
MCF 10A Volasertib
0.01
PLK
Cell cycle
 0.9466 0.01013
MCF 10A Volasertib
0.031623
PLK
Cell cycle
 0.1837 0.25023
MCF 10A Volasertib
0.1
PLK
Cell cycle
 -0.0850 0.41060
MCF 10A Volasertib
0.31623
PLK
Cell cycle
 -0.0849 0.41479
MCF 10A Volasertib
1.0
PLK
Cell cycle
 -0.0887 0.45252
MCF 10A Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0083 0.00069
MCF 10A Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.0143 0.00059