Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
---|---|---|---|---|---|---|
HCC1806 | INK-128 | 0.00031623 | mTORC1/2 | PI3K/mTOR | 0.8966 | 0.00900 |
HCC1806 | INK-128 | 0.001 | mTORC1/2 | PI3K/mTOR | 0.9546 | 0.00204 |
HCC1806 | INK-128 | 0.0031623 | mTORC1/2 | PI3K/mTOR | 0.8982 | 0.00402 |
HCC1806 | INK-128 | 0.01 | mTORC1/2 | PI3K/mTOR | 0.7903 | -0.00011 |
HCC1806 | INK-128 | 0.031623 | mTORC1/2 | PI3K/mTOR | 0.5319 | 0.03933 |
HCC1806 | INK-128 | 0.1 | mTORC1/2 | PI3K/mTOR | 0.4206 | 0.04042 |
HCC1806 | INK-128 | 0.31623 | mTORC1/2 | PI3K/mTOR | 0.3706 | 0.06159 |
HCC1806 | INK-128 | 1.0 | mTORC1/2 | PI3K/mTOR | 0.3388 | 0.06069 |
HCC1806 | INK-128 | 3.1623 | mTORC1/2 | PI3K/mTOR | 0.2620 | 0.10078 |
HCC1806 | PF-4708671 | 0.001 | p70S6K | PI3K/mTOR | 1.0152 | 0.00592 |
HCC1806 | PF-4708671 | 0.0031623 | p70S6K | PI3K/mTOR | 1.0299 | 0.00621 |
HCC1806 | PF-4708671 | 0.01 | p70S6K | PI3K/mTOR | 0.9556 | 0.00302 |
HCC1806 | PF-4708671 | 0.031623 | p70S6K | PI3K/mTOR | 1.0289 | 0.00535 |
HCC1806 | PF-4708671 | 0.1 | p70S6K | PI3K/mTOR | 1.0369 | -0.00429 |
HCC1806 | PF-4708671 | 0.31623 | p70S6K | PI3K/mTOR | 1.0125 | 0.00535 |
HCC1806 | PF-4708671 | 1.0 | p70S6K | PI3K/mTOR | 1.0192 | -0.00999 |
HCC1806 | PF-4708671 | 3.1623 | p70S6K | PI3K/mTOR | 1.1503 | -0.01604 |
HCC1806 | PF-4708671 | 10.0 | p70S6K | PI3K/mTOR | 1.2045 | -0.02488 |
HCC1806 | Buparlisib | 0.001 | pan PI3K | PI3K/mTOR | 0.9469 | 0.00201 |
HCC1806 | Buparlisib | 0.0031623 | pan PI3K | PI3K/mTOR | 0.9890 | 0.00172 |
HCC1806 | Buparlisib | 0.01 | pan PI3K | PI3K/mTOR | 1.0201 | 0.00194 |
HCC1806 | Buparlisib | 0.031623 | pan PI3K | PI3K/mTOR | 1.0031 | 0.00148 |
HCC1806 | Buparlisib | 0.1 | pan PI3K | PI3K/mTOR | 0.9540 | 0.00375 |
HCC1806 | Buparlisib | 0.31623 | pan PI3K | PI3K/mTOR | 0.8857 | 0.00696 |
HCC1806 | Buparlisib | 1.0 | pan PI3K | PI3K/mTOR | 0.5541 | 0.08134 |