LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 14 of 15: Time-dependent dose-response metrics for biological replicate 2. - Dataset (ID:20322)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Etoposide | 62.27 | 12.8 | Inf | Inf | -0.0470 | -0.0653 | 2.5000 | 0.5949 |
| MCF 10A-H2B-mCherry | Etoposide | 64.24 | 12.8 | Inf | Inf | -0.1610 | -0.2439 | 2.5000 | 0.6044 |
| MCF 10A-H2B-mCherry | Etoposide | 66.21 | 12.8 | Inf | Inf | -0.2675 | -0.3004 | 2.4999 | 0.5759 |
| MCF 10A-H2B-mCherry | Etoposide | 68.68 | 11.8 | Inf | Inf | -0.3486 | -0.3917 | 2.4998 | 0.6419 |
| MCF 10A-H2B-mCherry | Etoposide | 70.65 | 11.8 | 0.374 | 0.4184 | -0.4742 | -0.3943 | 5.0000 | 0.6342 |
| MCF 10A-H2B-mCherry | Etoposide | 72.62 | 11.8 | Inf | Inf | -0.4368 | -0.3631 | 2.5000 | 0.6217 |
| MCF 10A-H2B-mCherry | Etoposide | 74.59 | 11.8 | Inf | Inf | -0.4921 | -0.3975 | 2.5000 | 0.6448 |
| MCF 10A-H2B-mCherry | Etoposide | 76.56 | 11.8 | Inf | Inf | -0.5161 | -0.3658 | 2.5000 | 0.6176 |
| MCF 10A-H2B-mCherry | Etoposide | 78.53 | 11.8 | 0.4167 | 0.4886 | -0.6198 | -0.4902 | 4.5677 | 0.6156 |
| MCF 10A-H2B-mCherry | Etoposide | 80.50 | 11.8 | 0.4604 | 0.5628 | -0.5825 | -0.5212 | 4.2963 | 0.6204 |
| MCF 10A-H2B-mCherry | Etoposide | 82.47 | 11.8 | Inf | Inf | -0.6109 | -0.3921 | 2.5000 | 0.5753 |
| MCF 10A-H2B-mCherry | Etoposide | 84.44 | 11.8 | 0.5033 | 0.6125 | -0.4705 | -0.4504 | 4.9982 | 0.5433 |
| MCF 10A-H2B-mCherry | Etoposide | 86.41 | 11.8 | 0.5335 | 0.637 | -0.3779 | -0.3506 | 4.9992 | 0.4835 |
| MCF 10A-H2B-mCherry | Etoposide | 88.39 | 11.8 | 0.5141 | 0.6076 | -0.3934 | -0.3430 | 4.9994 | 0.4871 |
| MCF 10A-H2B-mCherry | Neratinib | 14.50 | 11.8 | 0.1014 | 0.0723 | 0.1817 | 0.1723 | 1.2230 | 0.3790 |
| MCF 10A-H2B-mCherry | Neratinib | 16.47 | 11.8 | 0.0475 | 0.0399 | 0.1640 | 0.1862 | 2.9328 | 0.4268 |
| MCF 10A-H2B-mCherry | Neratinib | 18.43 | 11.8 | 0.0448 | 0.0413 | 0.1418 | 0.1300 | 2.9533 | 0.4580 |
| MCF 10A-H2B-mCherry | Neratinib | 20.40 | 11.8 | 0.0393 | 0.034 | 0.0651 | 0.0625 | 0.9562 | 0.4912 |
| MCF 10A-H2B-mCherry | Neratinib | 22.37 | 11.8 | 0.0309 | 0.0304 | -0.0400 | 0.0052 | 0.9627 | 0.5264 |
| MCF 10A-H2B-mCherry | Neratinib | 24.34 | 11.8 | 0.0284 | 0.0292 | -0.0594 | 0.0081 | 1.1327 | 0.5345 |
| MCF 10A-H2B-mCherry | Neratinib | 26.31 | 11.8 | 0.0294 | 0.0356 | -0.1394 | -0.0698 | 0.9337 | 0.5476 |
| MCF 10A-H2B-mCherry | Neratinib | 28.28 | 11.8 | 0.0367 | 0.0686 | -0.2186 | -0.2457 | 0.8189 | 0.5478 |
| MCF 10A-H2B-mCherry | Neratinib | 30.24 | 11.8 | 0.0554 | 0.1098 | -0.2672 | -0.3266 | 0.8666 | 0.5194 |
| MCF 10A-H2B-mCherry | Neratinib | 32.22 | 11.8 | 0.0754 | 0.1236 | -0.2609 | -0.2950 | 0.9825 | 0.4833 |
| MCF 10A-H2B-mCherry | Neratinib | 34.19 | 11.8 | 0.0949 | 0.1275 | -0.2058 | -0.2119 | 1.2093 | 0.4546 |