LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Neratinib | 29.70 | 13.3 | 0.0674 | 0.0723 | -0.0647 | -0.0694 | 1.8850 | 0.4526 |
| MCF 10A-H2B-mCherry | Neratinib | 31.92 | 13.3 | 0.0841 | 0.0879 | -0.0517 | -0.0471 | 2.0558 | 0.4275 |
| MCF 10A-H2B-mCherry | Neratinib | 34.14 | 13.3 | 0.1196 | 0.1341 | -0.1261 | -0.1217 | 1.9993 | 0.4045 |
| MCF 10A-H2B-mCherry | Neratinib | 36.36 | 13.3 | 0.1326 | 0.1409 | -0.0797 | -0.0655 | 2.2307 | 0.3808 |
| MCF 10A-H2B-mCherry | Neratinib | 38.59 | 13.3 | 0.1536 | 0.1647 | -0.1192 | -0.0771 | 2.0651 | 0.3680 |
| MCF 10A-H2B-mCherry | Neratinib | 40.81 | 13.3 | 0.1858 | 0.193 | -0.1015 | -0.0501 | 2.5185 | 0.3352 |
| MCF 10A-H2B-mCherry | Neratinib | 43.03 | 13.3 | 0.2157 | 0.2249 | -0.1300 | -0.0547 | 2.6889 | 0.3076 |
| MCF 10A-H2B-mCherry | Neratinib | 45.25 | 13.3 | 0.2344 | 0.2372 | -0.1712 | -0.0290 | 4.7746 | 0.2829 |
| MCF 10A-H2B-mCherry | Neratinib | 47.47 | 13.3 | 0.2624 | 0.2623 | -0.0860 | -0.0002 | 4.4904 | 0.2689 |
| MCF 10A-H2B-mCherry | Neratinib | 49.69 | 13.3 | 0.2554 | 0.259 | -0.1281 | -0.0292 | 4.0237 | 0.2766 |
| MCF 10A-H2B-mCherry | Neratinib | 51.92 | 13.3 | 0.2723 | 0.2778 | -0.1512 | -0.0524 | 5.0000 | 0.2690 |
| MCF 10A-H2B-mCherry | Neratinib | 54.14 | 13.3 | 0.2668 | 0.2739 | -0.2193 | -0.0720 | 5.0000 | 0.2803 |
| MCF 10A-H2B-mCherry | Neratinib | 56.36 | 13.3 | 0.2871 | 0.2961 | -0.1936 | -0.0838 | 5.0000 | 0.2660 |
| MCF 10A-H2B-mCherry | Neratinib | 58.58 | 13.3 | 0.2979 | 0.3171 | -0.2579 | -0.1382 | 3.9404 | 0.2783 |
| MCF 10A-H2B-mCherry | Neratinib | 60.80 | 13.3 | 0.3174 | 0.3533 | -0.2819 | -0.1475 | 3.3545 | 0.2609 |
| MCF 10A-H2B-mCherry | Neratinib | 63.02 | 13.3 | 0.3984 | 0.4406 | -0.2414 | -0.1879 | 3.6088 | 0.2528 |
| MCF 10A-H2B-mCherry | Neratinib | 65.24 | 13.3 | 0.4103 | 0.49 | -0.3186 | -0.2875 | 3.4867 | 0.2705 |
| MCF 10A-H2B-mCherry | Neratinib | 67.47 | 13.3 | 0.5412 | 0.5856 | -0.2595 | -0.1969 | 3.8839 | 0.2374 |
| MCF 10A-H2B-mCherry | Neratinib | 69.71 | 13.4 | 0.5895 | 0.6414 | -0.3513 | -0.2624 | 5.0000 | 0.2420 |
| MCF 10A-H2B-mCherry | Neratinib | 71.94 | 13.4 | 0.8657 | 0.9895 | -0.3008 | -0.3025 | 4.0105 | 0.1919 |
| MCF 10A-H2B-mCherry | Neratinib | 74.16 | 13.4 | 1.0683 | 1.3539 | -0.4211 | -0.7255 | 3.7652 | 0.1930 |
| MCF 10A-H2B-mCherry | Neratinib | 76.38 | 13.4 | 1.1623 | 1.4074 | -0.3862 | -0.4851 | 3.9610 | 0.2050 |
| MCF 10A-H2B-mCherry | Neratinib | 78.60 | 13.4 | 1.6879 | 2.4766 | -0.2708 | -1.0000 | 3.5041 | 0.1709 |
| MCF 10A-H2B-mCherry | Neratinib | 80.82 | 13.4 | 2.3453 | 2.9216 | -0.1941 | -0.9999 | 5.0000 | 0.1566 |
| MCF 10A-H2B-mCherry | Palbociclib | 15.91 | 13.5 | 0.045 | 0.0365 | 0.1252 | 0.0905 | 0.9568 | 0.5703 |