LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Dasatinib | 69.71 | 13.4 | 2.5863 | 2.9033 | -0.3708 | -0.3922 | 5.0000 | 0.2048 |
| MCF 10A-H2B-mCherry | Neratinib | 69.71 | 13.4 | 0.5895 | 0.6414 | -0.3513 | -0.2624 | 5.0000 | 0.2420 |
| MCF 10A-H2B-mCherry | Taxol | 65.24 | 13.3 | 0.002 | 0.0022 | -0.3431 | -0.2472 | 4.2654 | 0.7033 |
| MCF 10A-H2B-mCherry | Neratinib | 65.24 | 13.3 | 0.4103 | 0.49 | -0.3186 | -0.2875 | 3.4867 | 0.2705 |
| MCF 10A-H2B-mCherry | Taxol | 47.47 | 13.3 | 0.0014 | 0.0016 | -0.3185 | -0.2225 | 3.3773 | 0.7193 |
| MCF 10A-H2B-mCherry | Dasatinib | 67.47 | 13.3 | 2.6267 | 2.9115 | -0.3174 | -0.3370 | 5.0000 | 0.2139 |
| MCF 10A-H2B-mCherry | Dasatinib | 65.24 | 13.3 | 2.6262 | 2.9014 | -0.3088 | -0.3272 | 5.0000 | 0.2266 |
| MCF 10A-H2B-mCherry | Taxol | 49.69 | 13.3 | 0.0016 | 0.0017 | -0.3046 | -0.2186 | 3.6106 | 0.7027 |
| MCF 10A-H2B-mCherry | Neratinib | 71.94 | 13.4 | 0.8657 | 0.9895 | -0.3008 | -0.3025 | 4.0105 | 0.1919 |
| MCF 10A-H2B-mCherry | Taxol | 45.25 | 13.3 | 0.0014 | 0.0016 | -0.2993 | -0.2321 | 3.0578 | 0.7257 |
| MCF 10A-H2B-mCherry | Neratinib | 60.80 | 13.3 | 0.3174 | 0.3533 | -0.2819 | -0.1475 | 3.3545 | 0.2609 |
| MCF 10A-H2B-mCherry | Taxol | 69.71 | 13.4 | 0.0023 | 0.0025 | -0.2735 | -0.1573 | 4.8802 | 0.6351 |
| MCF 10A-H2B-mCherry | Neratinib | 78.60 | 13.4 | 1.6879 | 2.4766 | -0.2708 | -1.0000 | 3.5041 | 0.1709 |
| MCF 10A-H2B-mCherry | Neratinib | 67.47 | 13.3 | 0.5412 | 0.5856 | -0.2595 | -0.1969 | 3.8839 | 0.2374 |
| MCF 10A-H2B-mCherry | Neratinib | 58.58 | 13.3 | 0.2979 | 0.3171 | -0.2579 | -0.1382 | 3.9404 | 0.2783 |
| MCF 10A-H2B-mCherry | Vorinostat | 16.73 | 13.3 | 0.6881 | 1.3581 | -0.2534 | -0.4659 | 0.9685 | 0.4010 |
| MCF 10A-H2B-mCherry | Dasatinib | 60.80 | 13.3 | 2.6142 | 2.8457 | -0.2483 | -0.2665 | 5.0000 | 0.2204 |
| MCF 10A-H2B-mCherry | Neratinib | 63.02 | 13.3 | 0.3984 | 0.4406 | -0.2414 | -0.1879 | 3.6088 | 0.2528 |
| MCF 10A-H2B-mCherry | Vorinostat | 18.59 | 13.3 | 0.5664 | 1.0687 | -0.2412 | -0.4101 | 0.9460 | 0.4283 |
| MCF 10A-H2B-mCherry | Dasatinib | 63.02 | 13.3 | 2.5721 | 2.791 | -0.2366 | -0.2566 | 5.0000 | 0.2329 |
| MCF 10A-H2B-mCherry | Vorinostat | 15.91 | 13.5 | 0.673 | 1.0022 | -0.2338 | -0.3147 | 1.2258 | 0.4090 |
| MCF 10A-H2B-mCherry | Taxol | 58.58 | 13.3 | 0.0017 | 0.0018 | -0.2303 | -0.1683 | 4.8617 | 0.6739 |
| MCF 10A-H2B-mCherry | Dasatinib | 58.58 | 13.3 | 2.2428 | 2.6437 | -0.2202 | -0.2823 | 3.2537 | 0.2503 |
| MCF 10A-H2B-mCherry | Neratinib | 54.14 | 13.3 | 0.2668 | 0.2739 | -0.2193 | -0.0720 | 5.0000 | 0.2803 |
| MCF 10A-H2B-mCherry | Vorinostat | 20.81 | 13.3 | 0.502 | 0.8536 | -0.2101 | -0.3304 | 0.9626 | 0.4380 |