LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Dasatinib | 67.47 | 13.3 | 2.6267 | 2.9115 | -0.3174 | -0.3370 | 5.0000 | 0.2139 |
| MCF 10A-H2B-mCherry | Dasatinib | 65.24 | 13.3 | 2.6262 | 2.9014 | -0.3088 | -0.3272 | 5.0000 | 0.2266 |
| MCF 10A-H2B-mCherry | Dasatinib | 63.02 | 13.3 | 2.5721 | 2.791 | -0.2366 | -0.2566 | 5.0000 | 0.2329 |
| MCF 10A-H2B-mCherry | Dasatinib | 60.80 | 13.3 | 2.6142 | 2.8457 | -0.2483 | -0.2665 | 5.0000 | 0.2204 |
| MCF 10A-H2B-mCherry | Vorinostat | 63.02 | 13.3 | 2.2236 | 2.2495 | -0.0400 | -0.0312 | 5.0000 | 0.1616 |
| MCF 10A-H2B-mCherry | Vorinostat | 65.24 | 13.3 | 2.4454 | 2.4775 | -0.0465 | -0.0353 | 5.0000 | 0.1445 |
| MCF 10A-H2B-mCherry | Vorinostat | 67.47 | 13.3 | 2.8259 | 2.865 | -0.0319 | -0.0356 | 5.0000 | 0.1279 |
| MCF 10A-H2B-mCherry | Vorinostat | 69.71 | 13.4 | 3.1094 | 3.0871 | 0.0108 | 0.0168 | 5.0000 | 0.1075 |
| MCF 10A-H2B-mCherry | Vorinostat | 71.94 | 13.4 | 3.2871 | 3.3126 | -0.0160 | -0.0202 | 5.0000 | 0.0996 |
| MCF 10A-H2B-mCherry | Vorinostat | 74.16 | 13.4 | 3.3307 | 3.3889 | -0.0246 | -0.0459 | 5.0000 | 0.1122 |
| MCF 10A-H2B-mCherry | Vorinostat | 76.38 | 13.4 | 3.3759 | 3.4083 | -0.0226 | -0.0245 | 5.0000 | 0.1154 |
| MCF 10A-H2B-mCherry | Vorinostat | 78.60 | 13.4 | 3.6487 | 3.6037 | 0.0164 | 0.0174 | 5.0000 | 0.0967 |
| MCF 10A-H2B-mCherry | Vorinostat | 80.82 | 13.4 | 3.3561 | 3.3984 | -0.0514 | -0.0324 | 5.0000 | 0.1236 |
| MCF 10A-H2B-mCherry | Neratinib | 51.92 | 13.3 | 0.2723 | 0.2778 | -0.1512 | -0.0524 | 5.0000 | 0.2690 |
| MCF 10A-H2B-mCherry | Neratinib | 54.14 | 13.3 | 0.2668 | 0.2739 | -0.2193 | -0.0720 | 5.0000 | 0.2803 |
| MCF 10A-H2B-mCherry | Neratinib | 56.36 | 13.3 | 0.2871 | 0.2961 | -0.1936 | -0.0838 | 5.0000 | 0.2660 |
| MCF 10A-H2B-mCherry | Neratinib | 69.71 | 13.4 | 0.5895 | 0.6414 | -0.3513 | -0.2624 | 5.0000 | 0.2420 |
| MCF 10A-H2B-mCherry | Taxol | 80.82 | 13.4 | 0.0029 | 0.0033 | -0.4208 | -0.4210 | 5.0000 | 0.7492 |
| MCF 10A-H2B-mCherry | Trametinib | 71.94 | 13.4 | 0.0301 | 0.0295 | -0.0284 | 0.0490 | 5.0000 | 0.3826 |
| MCF 10A-H2B-mCherry | Trametinib | 74.16 | 13.4 | 0.0303 | 0.0298 | -0.0034 | 0.0350 | 5.0000 | 0.3753 |
| MCF 10A-H2B-mCherry | Trametinib | 76.38 | 13.4 | 0.0309 | 0.0305 | -0.0623 | 0.0243 | 5.0000 | 0.3705 |
| MCF 10A-H2B-mCherry | Trametinib | 78.60 | 13.4 | 0.0337 | 0.0328 | 0.0005 | 0.0659 | 5.0000 | 0.3496 |
| MCF 10A-H2B-mCherry | Taxol | 78.60 | 13.4 | 0.0027 | 0.003 | -0.4567 | -0.3897 | 5.0000 | 0.7535 |