LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Dasatinib | 51.92 | 13.3 | 1.7473 | 4.2745 | -0.1576 | -0.6600 | 1.3427 | 0.2569 |
| MCF 10A-H2B-mCherry | Dasatinib | 45.25 | 13.3 | 1.0589 | 4.5149 | -0.0802 | -0.7836 | 0.6356 | 0.2946 |
| MCF 10A-H2B-mCherry | Alpelisib | 31.92 | 13.3 | Inf | 48.0469 | 0.6505 | -0.3257 | 0.5441 | 0.0840 |
| MCF 10A-H2B-mCherry | Alpelisib | 25.25 | 13.3 | 13.7447 | 50.8693 | 0.5662 | -0.9329 | 0.8377 | 0.0699 |
| MCF 10A-H2B-mCherry | Palbociclib | 78.60 | 13.4 | 3.8114 | 5.377 | -0.0290 | -0.5698 | 2.1381 | 0.1010 |
| MCF 10A-H2B-mCherry | Palbociclib | 69.71 | 13.4 | 3.1977 | 5.394 | -0.0186 | -0.4657 | 1.2682 | 0.1393 |
| MCF 10A-H2B-mCherry | Dasatinib | 47.47 | 13.3 | 1.2344 | 5.6634 | -0.1100 | -0.9056 | 0.6840 | 0.2827 |
| MCF 10A-H2B-mCherry | Dasatinib | 49.69 | 13.3 | 1.5612 | 5.8184 | -0.1606 | -0.9355 | 0.8455 | 0.2645 |
| MCF 10A-H2B-mCherry | Palbociclib | 65.24 | 13.3 | 1.9881 | 6.2593 | -0.0570 | -0.7577 | 0.8015 | 0.1967 |
| MCF 10A-H2B-mCherry | Alpelisib | 38.59 | 13.3 | Inf | 659.7431 | 0.7083 | -0.8898 | 0.4399 | 0.0784 |
| MCF 10A-H2B-mCherry | Alpelisib | 23.04 | 13.3 | 13.0191 | 67.1327 | 0.5327 | -1.0000 | 0.6881 | 0.0949 |
| MCF 10A-H2B-mCherry | Palbociclib | 80.82 | 13.4 | 4.3569 | 6.7523 | -0.0503 | -0.7295 | 1.9672 | 0.0940 |
| MCF 10A-H2B-mCherry | Alpelisib | 43.03 | 13.3 | 23.3924 | 88.1783 | 0.7153 | -0.9969 | 0.8352 | 0.0518 |
| MCF 10A-H2B-mCherry | Alpelisib | 60.80 | 13.3 | Inf | Inf | 0.7722 | 0.8272 | 1.1247 | 0.0073 |
| MCF 10A-H2B-mCherry | Alpelisib | 69.71 | 13.4 | Inf | Inf | 0.8659 | 0.8659 | 0.0000 | 0.0193 |
| MCF 10A-H2B-mCherry | Alpelisib | 71.94 | 13.4 | Inf | Inf | 0.9804 | 0.9804 | 0.0000 | -0.0105 |
| MCF 10A-H2B-mCherry | Alpelisib | 74.16 | 13.4 | Inf | Inf | 1.0285 | 1.0285 | 0.0000 | -0.0023 |
| MCF 10A-H2B-mCherry | Alpelisib | 76.38 | 13.4 | Inf | Inf | 0.9533 | 0.9533 | 0.0000 | -0.0076 |
| MCF 10A-H2B-mCherry | Alpelisib | 78.60 | 13.4 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0077 |
| MCF 10A-H2B-mCherry | Alpelisib | 80.82 | 13.4 | Inf | Inf | 0.9804 | 0.9804 | 0.0000 | -0.0023 |
| MCF 10A-H2B-mCherry | Alpelisib | 65.24 | 13.3 | Inf | Inf | 0.7691 | 0.8264 | 2.5000 | 0.0249 |
| MCF 10A-H2B-mCherry | Alpelisib | 63.02 | 13.3 | Inf | Inf | 0.8310 | 0.8049 | 0.7013 | 0.0213 |
| MCF 10A-H2B-mCherry | Alpelisib | 67.47 | 13.3 | Inf | Inf | 0.8446 | 0.8821 | 2.5000 | 0.0200 |