LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Etoposide | 43.03 | 13.3 | 0.3068 | 0.3252 | -0.0297 | -0.0422 | 1.3917 | 0.3968 |
| MCF 10A-H2B-mCherry | Etoposide | 45.25 | 13.3 | 0.3409 | 0.3531 | -0.0447 | -0.0288 | 1.5973 | 0.3781 |
| MCF 10A-H2B-mCherry | Etoposide | 47.47 | 13.3 | 0.3524 | 0.3666 | -0.0480 | -0.0310 | 1.5731 | 0.3820 |
| MCF 10A-H2B-mCherry | Etoposide | 49.69 | 13.3 | 0.3623 | 0.3866 | -0.0876 | -0.0529 | 1.5251 | 0.3843 |
| MCF 10A-H2B-mCherry | Etoposide | 51.92 | 13.3 | 0.3778 | 0.4154 | -0.0733 | -0.0711 | 1.3931 | 0.3799 |
| MCF 10A-H2B-mCherry | Etoposide | 54.14 | 13.3 | 0.359 | 0.3734 | -0.0172 | -0.0276 | 1.4319 | 0.3826 |
| MCF 10A-H2B-mCherry | Etoposide | 56.36 | 13.3 | 0.3542 | 0.3472 | -0.0096 | 0.0162 | 1.7706 | 0.3758 |
| MCF 10A-H2B-mCherry | Etoposide | 58.58 | 13.3 | 0.3473 | 0.3426 | 0.0137 | 0.0129 | 1.9918 | 0.3751 |
| MCF 10A-H2B-mCherry | Etoposide | 60.80 | 13.3 | 0.3928 | 0.3854 | -0.0303 | 0.0119 | 2.0442 | 0.3554 |
| MCF 10A-H2B-mCherry | Etoposide | 63.02 | 13.3 | 0.4032 | 0.4185 | -0.0977 | -0.0339 | 2.2677 | 0.3679 |
| MCF 10A-H2B-mCherry | Etoposide | 65.24 | 13.3 | 0.4362 | 0.4435 | -0.0514 | -0.0090 | 3.4977 | 0.3579 |
| MCF 10A-H2B-mCherry | Etoposide | 67.47 | 13.3 | 0.4785 | 0.4894 | -0.0855 | -0.0237 | 3.4838 | 0.3477 |
| MCF 10A-H2B-mCherry | Etoposide | 69.71 | 13.4 | 0.5077 | 0.5252 | -0.1330 | -0.0302 | 3.4199 | 0.3350 |
| MCF 10A-H2B-mCherry | Etoposide | 71.94 | 13.4 | 0.541 | 0.5582 | -0.0714 | -0.0338 | 3.5133 | 0.3384 |
| MCF 10A-H2B-mCherry | Etoposide | 74.16 | 13.4 | 0.4975 | 0.5185 | -0.1472 | -0.0736 | 3.8402 | 0.3713 |
| MCF 10A-H2B-mCherry | Etoposide | 76.38 | 13.4 | 0.4846 | 0.465 | -0.0425 | 0.0666 | 4.0059 | 0.3424 |
| MCF 10A-H2B-mCherry | Etoposide | 78.60 | 13.4 | 0.4984 | 0.5033 | -0.1109 | -0.0202 | 3.8858 | 0.3607 |
| MCF 10A-H2B-mCherry | Etoposide | 80.82 | 13.4 | 0.4706 | 0.4799 | -0.2090 | -0.0541 | 4.9985 | 0.3977 |
| MCF 10A-H2B-mCherry | Neratinib | 15.91 | 13.5 | 0.0344 | 0.0274 | 0.1224 | 0.1444 | 1.4878 | 0.4548 |
| MCF 10A-H2B-mCherry | Neratinib | 16.73 | 13.3 | 0.0359 | 0.03 | 0.1415 | 0.1416 | 1.8404 | 0.4507 |
| MCF 10A-H2B-mCherry | Neratinib | 18.59 | 13.3 | 0.0297 | 0.0273 | 0.0756 | 0.0682 | 1.7219 | 0.4978 |
| MCF 10A-H2B-mCherry | Neratinib | 20.81 | 13.3 | 0.0279 | 0.0275 | 0.0316 | 0.0136 | 1.8649 | 0.5263 |
| MCF 10A-H2B-mCherry | Neratinib | 23.04 | 13.3 | 0.0319 | 0.033 | -0.0397 | -0.0347 | 1.9183 | 0.5310 |
| MCF 10A-H2B-mCherry | Neratinib | 25.25 | 13.3 | 0.0402 | 0.0424 | -0.0254 | -0.0486 | 1.8311 | 0.5029 |
| MCF 10A-H2B-mCherry | Neratinib | 27.48 | 13.3 | 0.0548 | 0.0589 | -0.0557 | -0.0726 | 1.9015 | 0.4791 |