LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 9 of 15: End-point dose-response metrics for biological replicate 3. - Dataset (ID:20317)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Vorinostat | 48 | 0.6114 | 0.9444 | -0.0821 | -0.2429 | 0.9107 | 0.4110 |
| MCF 10A-H2B-mCherry | Palbociclib | 48 | 3.3346 | 999.9941 | 0.3630 | -0.7979 | 0.1673 | 0.3254 |
| MCF 10A-H2B-mCherry | Taxol | 48 | 0.0013 | 0.0019 | -0.3312 | -0.2815 | 1.1758 | 0.7519 |
| MCF 10A-H2B-mCherry | Trametinib | 48 | Inf | 0.0005 | 0.5447 | 0.5288 | 0.5177 | 0.3751 |
| MCF 10A-H2B-mCherry | Etoposide | 48 | 1.1834 | 37.3253 | 0.1896 | -1.0000 | 0.3183 | 0.3192 |
| MCF 10A-H2B-mCherry | Alpelisib | 48 | Inf | Inf | 0.7129 | 0.7129 | 0.0000 | 0.1620 |
| MCF 10A-H2B-mCherry | Dasatinib | 48 | 1.2987 | 299.0185 | 0.3294 | -1.0000 | 0.2020 | 0.3592 |
| MCF 10A-H2B-mCherry | Palbociclib | 60 | 2.6707 | 808.9177 | 0.3136 | -1.0000 | 0.1923 | 0.3179 |
| MCF 10A-H2B-mCherry | Vorinostat | 60 | 0.7223 | 1.0618 | -0.0810 | -0.2268 | 0.9711 | 0.3866 |
| MCF 10A-H2B-mCherry | Taxol | 60 | 0.0011 | 0.0014 | -0.3195 | -0.2487 | 1.3756 | 0.7703 |
| MCF 10A-H2B-mCherry | Trametinib | 60 | 0.2951 | 0.0015 | 0.5078 | 0.4730 | 0.5502 | 0.3764 |
| MCF 10A-H2B-mCherry | Neratinib | 60 | 0.2207 | 3.2708 | -0.0756 | -1.0000 | 0.4075 | 0.3689 |
| MCF 10A-H2B-mCherry | Alpelisib | 60 | Inf | Inf | 0.7342 | 0.7342 | 0.0000 | 0.1444 |
| MCF 10A-H2B-mCherry | Dasatinib | 60 | 1.0757 | 102.3859 | 0.1735 | -1.0000 | 0.2412 | 0.3555 |
| MCF 10A-H2B-mCherry | Etoposide | 60 | 0.847 | 16.3367 | 0.1412 | -0.8621 | 0.3387 | 0.3416 |
| MCF 10A-H2B-mCherry | Taxol | 72 | 0.001 | 0.0013 | -0.3180 | -0.2585 | 1.4036 | 0.7880 |
| MCF 10A-H2B-mCherry | Vorinostat | 72 | 0.8282 | 1.127 | -0.0873 | -0.2023 | 1.1031 | 0.3632 |
| MCF 10A-H2B-mCherry | Trametinib | 72 | 0.0717 | 0.0063 | 0.3482 | 0.3285 | 0.4390 | 0.3784 |
| MCF 10A-H2B-mCherry | Palbociclib | 72 | 2.3133 | 319.7903 | 0.2433 | -1.0000 | 0.2229 | 0.3116 |
| MCF 10A-H2B-mCherry | Alpelisib | 72 | Inf | Inf | 0.7448 | 0.7448 | 0.0000 | 0.1385 |
| MCF 10A-H2B-mCherry | Dasatinib | 72 | 0.8672 | 64.7283 | 0.0603 | -1.0000 | 0.2547 | 0.3653 |
| MCF 10A-H2B-mCherry | Etoposide | 72 | 0.5612 | 1.2244 | 0.1419 | -0.2015 | 0.4341 | 0.3610 |
| MCF 10A-H2B-mCherry | Neratinib | 72 | 0.246 | 2.6692 | -0.1124 | -1.0000 | 0.4607 | 0.3588 |
| MCF 10A-H2B-mCherry | Trametinib | 84 | 0.1232 | 0.0231 | 0.3664 | 0.2222 | 0.3508 | 0.3587 |
| MCF 10A-H2B-mCherry | Taxol | 84 | 0.0009 | 0.0012 | -0.3444 | -0.2890 | 1.3812 | 0.8153 |