Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) - Dataset (ID:20276)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Number of Cells Primary Antibody (488) Secondary Antibody (488) Protein Detected (488) Mean Fluorescence Intensity (488) Primary Antibody (647) Secondary Antibody (647) Protein Detected (647) Mean Fluorescence Intensity (647) Plate Name Plate Well
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1088 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 136.47 NGFR rabbit IgG(H+L) / donkey NGFR 155.22
A375-A2-rep1
H10
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1210 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 152.35 NGFR rabbit IgG(H+L) / donkey NGFR 155.16
A375-A2-rep1
H11
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1206 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 152.77 NGFR rabbit IgG(H+L) / donkey NGFR 156.70
A375-A2-rep1
H2
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1034 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 152.56 NGFR rabbit IgG(H+L) / donkey NGFR 144.52
A375-A2-rep1
H3
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1004 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 142.24 NGFR rabbit IgG(H+L) / donkey NGFR 122.61
A375-A2-rep1
H4
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 955 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 144.67 NGFR rabbit IgG(H+L) / donkey NGFR 131.81
A375-A2-rep1
H5
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 969 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 161.13 NGFR rabbit IgG(H+L) / donkey NGFR 146.47
A375-A2-rep1
H6
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1074 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 168.31 NGFR rabbit IgG(H+L) / donkey NGFR 161.00
A375-A2-rep1
H7
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1099 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 168.81 NGFR rabbit IgG(H+L) / donkey NGFR 136.50
A375-A2-rep1
H8
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1087 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 149.27 NGFR rabbit IgG(H+L) / donkey NGFR 138.42
A375-A2-rep1
H9
A-375 Vemurafenib IOX2 1.0000 2.6667
uM
 48
hr
 1 2950 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 154.83 NGFR rabbit IgG(H+L) / donkey NGFR 183.99
A375-A2-rep1
D8
A-375 Vemurafenib GSK-J1 1.0000 2.6667
uM
 48
hr
 1 2495 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 184.65 NGFR rabbit IgG(H+L) / donkey NGFR 225.50
A375-A2-rep1
B6
A-375 Vemurafenib Azacitidine 1.0000 2.6667
uM
 48
hr
 1 1210 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 261.75 NGFR rabbit IgG(H+L) / donkey NGFR 53.65
A375-A2-rep1
E2
A-375 Vemurafenib PFI-1 1.0000 2.6667
uM
 48
hr
 1 2255 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 142.05 NGFR rabbit IgG(H+L) / donkey NGFR 162.18
A375-A2-rep1
B7
A-375 Vemurafenib C646 1.0000 2.6667
uM
 48
hr
 1 2172 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 156.52 NGFR rabbit IgG(H+L) / donkey NGFR 184.53
A375-A2-rep1
E3
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2008 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 185.44 NGFR rabbit IgG(H+L) / donkey NGFR 205.73
A375-A2-rep1
A3
A-375 Vemurafenib Mocetinostat 1.0000 2.6667
uM
 48
hr
 1 304 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 299.57 NGFR rabbit IgG(H+L) / donkey NGFR 87.98
A375-A2-rep1
E4
A-375 Vemurafenib UNC669 1.0000 2.6667
uM
 48
hr
 1 2298 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 153.06 NGFR rabbit IgG(H+L) / donkey NGFR 186.36
A375-A2-rep1
B8
A-375 Vemurafenib Resveratrol 1.0000 2.6667
uM
 48
hr
 1 2505 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 181.88 NGFR rabbit IgG(H+L) / donkey NGFR 186.11
A375-A2-rep1
E5
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2160 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 190.11 NGFR rabbit IgG(H+L) / donkey NGFR 151.59
A375-B1-rep1
A2
A-375 Vemurafenib Daminozide 1.0000 2.6667
uM
 48
hr
 1 2676 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 168.16 NGFR rabbit IgG(H+L) / donkey NGFR 205.28
A375-A2-rep1
E6
A-375 Vemurafenib Veliparib 1.0000 2.6667
uM
 48
hr
 1 2081 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 171.06 NGFR rabbit IgG(H+L) / donkey NGFR 200.69
A375-A2-rep1
C2
A-375 Vemurafenib I-BET 1.0000 2.6667
uM
 48
hr
 1 2375 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 130.55 NGFR rabbit IgG(H+L) / donkey NGFR 81.67
A375-A2-rep1
E7
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2330 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 161.10 NGFR rabbit IgG(H+L) / donkey NGFR 180.27
A375-B1-rep1
A6
A-375 Vemurafenib Rocilinostat 1.0000 0.5333
uM
 48
hr
 1 3162 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 282.48 NGFR rabbit IgG(H+L) / donkey NGFR 131.05
A375-B1-rep1
B5