Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) - Dataset (ID:20276)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Number of Cells Primary Antibody (488) Secondary Antibody (488) Protein Detected (488) Mean Fluorescence Intensity (488) Primary Antibody (647) Secondary Antibody (647) Protein Detected (647) Mean Fluorescence Intensity (647) Plate Name Plate Well
COLO 858 Vemurafenib Mocetinostat 0.3160 0.1067
uM
 48
hr
 2 3092 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 219.79 NGFR rabbit IgG(H+L) / donkey NGFR 83.00
Colo858-B2-rep2
E4
A-375 Vemurafenib Daminozide 1.0000 0.5333
uM
 48
hr
 2 3093 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 188.94 NGFR rabbit IgG(H+L) / donkey NGFR 179.22
A375-B1-rep2
E6
COLO 858 Vemurafenib (-)-JQ1 0.3160 2.6667
uM
 48
hr
 2 3101 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 297.94 NGFR rabbit IgG(H+L) / donkey NGFR 134.38
Colo858-A2-rep2
D7
COLO 858 Vemurafenib Epigallocatechin gallate 0.3160 2.6667
uM
 48
hr
 1 3105 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 357.79 NGFR rabbit IgG(H+L) / donkey NGFR 132.41
Colo858-A2-rep1
E8
COLO 858 Vemurafenib Daminozide 0.3160 2.6667
uM
 48
hr
 2 3110 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 319.78 NGFR rabbit IgG(H+L) / donkey NGFR 135.02
Colo858-A2-rep2
E6
A-375 Vemurafenib GSK-J2 1.0000 0.5333
uM
 48
hr
 2 3124 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 156.22 NGFR rabbit IgG(H+L) / donkey NGFR 175.54
A375-B1-rep2
C6
COLO 858 Vemurafenib Resveratrol 0.3160 0.1067
uM
 48
hr
 2 3137 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 346.17 NGFR rabbit IgG(H+L) / donkey NGFR 157.63
Colo858-B2-rep2
E5
A-375 Vemurafenib Selisistat 1.0000 0.1067
uM
 48
hr
 1 3138 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 229.27 NGFR rabbit IgG(H+L) / donkey NGFR 239.03
A375-B2-rep1
C5
A-375 Vemurafenib Pracinostat 1.0000 0.1067
uM
 48
hr
 2 3139 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 547.64 NGFR rabbit IgG(H+L) / donkey NGFR 127.96
A375-B2-rep2
F4
A-375 Vemurafenib IOX2 1.0000 0.1067
uM
 48
hr
 1 3139 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 180.23 NGFR rabbit IgG(H+L) / donkey NGFR 204.69
A375-B2-rep1
D8
COLO 858 Vemurafenib Daminozide 0.3160 0.5333
uM
 48
hr
 2 3157 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 329.58 NGFR rabbit IgG(H+L) / donkey NGFR 139.83
Colo858-B1-rep2
E6
A-375 Vemurafenib Rocilinostat 1.0000 0.5333
uM
 48
hr
 1 3162 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 282.48 NGFR rabbit IgG(H+L) / donkey NGFR 131.05
A375-B1-rep1
B5
COLO 858 Vemurafenib Daminozide 0.3160 0.1067
uM
 48
hr
 2 3171 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 314.34 NGFR rabbit IgG(H+L) / donkey NGFR 161.15
Colo858-B2-rep2
E6
COLO 858 Vemurafenib (-)-JQ1 0.3160 2.6667
uM
 48
hr
 1 3175 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 309.67 NGFR rabbit IgG(H+L) / donkey NGFR 140.73
Colo858-A2-rep1
D7
A-375 Vemurafenib (-)-JQ1 1.0000 0.1067
uM
 48
hr
 1 3182 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 171.84 NGFR rabbit IgG(H+L) / donkey NGFR 203.99
A375-B2-rep1
D7
COLO 858 Vemurafenib IOX2 0.3160 0.1067
uM
 48
hr
 2 3195 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 403.34 NGFR rabbit IgG(H+L) / donkey NGFR 186.02
Colo858-B2-rep2
D8
A-375 Vemurafenib Daminozide 1.0000 0.1067
uM
 48
hr
 2 3195 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 177.92 NGFR rabbit IgG(H+L) / donkey NGFR 177.56
A375-B2-rep2
E6
COLO 858 Vemurafenib IOX2 0.3160 2.6667
uM
 48
hr
 2 3207 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 355.43 NGFR rabbit IgG(H+L) / donkey NGFR 154.65
Colo858-A2-rep2
D8
A-375 Vemurafenib (-)-JQ1 1.0000 0.5333
uM
 48
hr
 1 3215 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 162.83 NGFR rabbit IgG(H+L) / donkey NGFR 203.67
A375-B1-rep1
D7
A-375 Vemurafenib Selisistat 1.0000 2.6667
uM
 48
hr
 2 3238 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 195.56 NGFR rabbit IgG(H+L) / donkey NGFR 217.60
A375-A2-rep2
C5
A-375 Vemurafenib GSK-J4 1.0000 0.1067
uM
 48
hr
 2 3245 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 160.22 NGFR rabbit IgG(H+L) / donkey NGFR 162.74
A375-B2-rep2
D6
COLO 858 Vemurafenib IOX2 0.3160 0.1067
uM
 48
hr
 1 3247 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 296.22 NGFR rabbit IgG(H+L) / donkey NGFR 170.23
Colo858-B2-rep1
D8
A-375 Vemurafenib Entinostat 1.0000 0.1067
uM
 48
hr
 2 3256 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 245.92 NGFR rabbit IgG(H+L) / donkey NGFR 251.65
A375-B2-rep2
D4
A-375 Vemurafenib AGK2 1.0000 0.1067
uM
 48
hr
 2 3264 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 185.18 NGFR rabbit IgG(H+L) / donkey NGFR 175.19
A375-B2-rep2
D5
A-375 Vemurafenib GSK-J2 1.0000 0.1067
uM
 48
hr
 1 3266 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 196.57 NGFR rabbit IgG(H+L) / donkey NGFR 202.00
A375-B2-rep1
C6