Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) - Dataset (ID:20276)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Number of Cells Primary Antibody (488) Secondary Antibody (488) Protein Detected (488) Mean Fluorescence Intensity (488) Primary Antibody (647) Secondary Antibody (647) Protein Detected (647) Mean Fluorescence Intensity (647) Plate Name Plate Well
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1322 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 192.92 NGFR rabbit IgG(H+L) / donkey NGFR 134.13
A375-A2-rep2
H6
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1203 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 180.96 NGFR rabbit IgG(H+L) / donkey NGFR 155.39
A375-A2-rep2
H7
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1323 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 195.90 NGFR rabbit IgG(H+L) / donkey NGFR 165.15
A375-A2-rep2
H8
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1550 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 209.64 NGFR rabbit IgG(H+L) / donkey NGFR 158.29
A375-A2-rep2
H9
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1907 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 181.83 NGFR rabbit IgG(H+L) / donkey NGFR 159.59
A375-B1-rep1
A10
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1748 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 184.19 NGFR rabbit IgG(H+L) / donkey NGFR 174.69
A375-B1-rep1
A11
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2160 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 190.11 NGFR rabbit IgG(H+L) / donkey NGFR 151.59
A375-B1-rep1
A2
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2235 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 168.50 NGFR rabbit IgG(H+L) / donkey NGFR 181.65
A375-B1-rep1
A3
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2553 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 159.96 NGFR rabbit IgG(H+L) / donkey NGFR 170.70
A375-B1-rep1
A4
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2318 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 158.52 NGFR rabbit IgG(H+L) / donkey NGFR 169.15
A375-B1-rep1
A5
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2330 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 161.10 NGFR rabbit IgG(H+L) / donkey NGFR 180.27
A375-B1-rep1
A6
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2044 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 167.93 NGFR rabbit IgG(H+L) / donkey NGFR 183.52
A375-B1-rep1
A7
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2248 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 151.33 NGFR rabbit IgG(H+L) / donkey NGFR 175.00
A375-B1-rep1
A8
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2222 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 152.21 NGFR rabbit IgG(H+L) / donkey NGFR 164.68
A375-B1-rep1
A9
A-375 Vemurafenib Olaparib 1.0000 0.5333
uM
 48
hr
 1 2160 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 155.98 NGFR rabbit IgG(H+L) / donkey NGFR 170.41
A375-B1-rep1
B2
A-375 Vemurafenib Iniparib 1.0000 0.5333
uM
 48
hr
 1 2558 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 162.66 NGFR rabbit IgG(H+L) / donkey NGFR 177.45
A375-B1-rep1
B3
A-375 Vemurafenib CTB 1.0000 0.5333
uM
 48
hr
 1 2506 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 147.12 NGFR rabbit IgG(H+L) / donkey NGFR 144.19
A375-B1-rep1
B4
A-375 Vemurafenib Rocilinostat 1.0000 0.5333
uM
 48
hr
 1 3162 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 282.48 NGFR rabbit IgG(H+L) / donkey NGFR 131.05
A375-B1-rep1
B5
A-375 Vemurafenib GSK-J1 1.0000 0.5333
uM
 48
hr
 1 2570 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 160.48 NGFR rabbit IgG(H+L) / donkey NGFR 156.00
A375-B1-rep1
B6
A-375 Vemurafenib PFI-1 1.0000 0.5333
uM
 48
hr
 1 2521 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 154.70 NGFR rabbit IgG(H+L) / donkey NGFR 191.24
A375-B1-rep1
B7
A-375 Vemurafenib UNC669 1.0000 0.5333
uM
 48
hr
 1 2511 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 175.77 NGFR rabbit IgG(H+L) / donkey NGFR 171.25
A375-B1-rep1
B8
A-375 Vemurafenib Veliparib 1.0000 0.5333
uM
 48
hr
 1 2207 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 158.60 NGFR rabbit IgG(H+L) / donkey NGFR 168.87
A375-B1-rep1
C2
A-375 Vemurafenib Rucaparib 1.0000 0.5333
uM
 48
hr
 1 2388 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 144.69 NGFR rabbit IgG(H+L) / donkey NGFR 175.61
A375-B1-rep1
C3
A-375 Vemurafenib Belinostat 1.0000 0.5333
uM
 48
hr
 1 1911 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 160.06 NGFR rabbit IgG(H+L) / donkey NGFR 19.85
A375-B1-rep1
C4
A-375 Vemurafenib Selisistat 1.0000 0.5333
uM
 48
hr
 1 3060 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 183.87 NGFR rabbit IgG(H+L) / donkey NGFR 195.84
A375-B1-rep1
C5