Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) - Dataset (ID:20276)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Number of Cells Primary Antibody (488) Secondary Antibody (488) Protein Detected (488) Mean Fluorescence Intensity (488) Primary Antibody (647) Secondary Antibody (647) Protein Detected (647) Mean Fluorescence Intensity (647) Plate Name Plate Well
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1797 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 197.36 NGFR rabbit IgG(H+L) / donkey NGFR 224.46
A375-A2-rep2
A7
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1871 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 184.59 NGFR rabbit IgG(H+L) / donkey NGFR 210.13
A375-A2-rep2
A8
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 2409 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 178.97 NGFR rabbit IgG(H+L) / donkey NGFR 199.27
A375-A2-rep2
A9
A-375 Vemurafenib Olaparib 1.0000 2.6667
uM
 48
hr
 2 2229 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 159.21 NGFR rabbit IgG(H+L) / donkey NGFR 210.77
A375-A2-rep2
B2
A-375 Vemurafenib Iniparib 1.0000 2.6667
uM
 48
hr
 2 2597 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 177.05 NGFR rabbit IgG(H+L) / donkey NGFR 176.99
A375-A2-rep2
B3
A-375 Vemurafenib CTB 1.0000 2.6667
uM
 48
hr
 2 2634 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 183.35 NGFR rabbit IgG(H+L) / donkey NGFR 163.76
A375-A2-rep2
B4
A-375 Vemurafenib Rocilinostat 1.0000 2.6667
uM
 48
hr
 2 2940 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 277.54 NGFR rabbit IgG(H+L) / donkey NGFR 76.23
A375-A2-rep2
B5
A-375 Vemurafenib GSK-J1 1.0000 2.6667
uM
 48
hr
 2 2734 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 198.78 NGFR rabbit IgG(H+L) / donkey NGFR 231.75
A375-A2-rep2
B6
A-375 Vemurafenib PFI-1 1.0000 2.6667
uM
 48
hr
 2 2464 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 137.44 NGFR rabbit IgG(H+L) / donkey NGFR 154.43
A375-A2-rep2
B7
A-375 Vemurafenib UNC669 1.0000 2.6667
uM
 48
hr
 2 2373 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 210.68 NGFR rabbit IgG(H+L) / donkey NGFR 209.48
A375-A2-rep2
B8
A-375 Vemurafenib Veliparib 1.0000 2.6667
uM
 48
hr
 2 2511 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 190.08 NGFR rabbit IgG(H+L) / donkey NGFR 181.11
A375-A2-rep2
C2
A-375 Vemurafenib Rucaparib 1.0000 2.6667
uM
 48
hr
 2 2477 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 156.42 NGFR rabbit IgG(H+L) / donkey NGFR 200.11
A375-A2-rep2
C3
A-375 Vemurafenib Belinostat 1.0000 2.6667
uM
 48
hr
 2 319 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 360.58 NGFR rabbit IgG(H+L) / donkey NGFR 26.94
A375-A2-rep2
C4
A-375 Vemurafenib Selisistat 1.0000 2.6667
uM
 48
hr
 2 3238 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 195.56 NGFR rabbit IgG(H+L) / donkey NGFR 217.60
A375-A2-rep2
C5
A-375 Vemurafenib GSK-J2 1.0000 2.6667
uM
 48
hr
 2 3289 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 175.33 NGFR rabbit IgG(H+L) / donkey NGFR 210.26
A375-A2-rep2
C6
A-375 Vemurafenib (+)-JQ1 1.0000 2.6667
uM
 48
hr
 2 2251 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 165.40 NGFR rabbit IgG(H+L) / donkey NGFR 86.81
A375-A2-rep2
C7
A-375 Vemurafenib UNC1215 1.0000 2.6667
uM
 48
hr
 2 2981 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 185.94 NGFR rabbit IgG(H+L) / donkey NGFR 204.11
A375-A2-rep2
C8
A-375 Vemurafenib Vorinostat 1.0000 2.6667
uM
 48
hr
 2 2222 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 252.58 NGFR rabbit IgG(H+L) / donkey NGFR 61.42
A375-A2-rep2
D2
A-375 Vemurafenib JW55 1.0000 2.6667
uM
 48
hr
 2 2911 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 155.15 NGFR rabbit IgG(H+L) / donkey NGFR 159.22
A375-A2-rep2
D3
A-375 Vemurafenib Entinostat 1.0000 2.6667
uM
 48
hr
 2 3308 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 589.21 NGFR rabbit IgG(H+L) / donkey NGFR 306.13
A375-A2-rep2
D4
A-375 Vemurafenib AGK2 1.0000 2.6667
uM
 48
hr
 2 1329 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 425.48 NGFR rabbit IgG(H+L) / donkey NGFR 176.32
A375-A2-rep2
D5
A-375 Vemurafenib GSK-J4 1.0000 2.6667
uM
 48
hr
 2 1738 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 131.40 NGFR rabbit IgG(H+L) / donkey NGFR 104.43
A375-A2-rep2
D6
A-375 Vemurafenib (-)-JQ1 1.0000 2.6667
uM
 48
hr
 2 3409 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 167.33 NGFR rabbit IgG(H+L) / donkey NGFR 293.21
A375-A2-rep2
D7
A-375 Vemurafenib IOX2 1.0000 2.6667
uM
 48
hr
 2 2998 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 182.38 NGFR rabbit IgG(H+L) / donkey NGFR 220.87
A375-A2-rep2
D8
A-375 Vemurafenib Azacitidine 1.0000 2.6667
uM
 48
hr
 2 1303 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 286.33 NGFR rabbit IgG(H+L) / donkey NGFR 62.73
A375-A2-rep2
E2