Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) - Dataset (ID:20276)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Number of Cells Primary Antibody (488) Secondary Antibody (488) Protein Detected (488) Mean Fluorescence Intensity (488) Primary Antibody (647) Secondary Antibody (647) Protein Detected (647) Mean Fluorescence Intensity (647) Plate Name Plate Well
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1588 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 159.67 NGFR rabbit IgG(H+L) / donkey NGFR 144.38
A375-B2-rep1
H8
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1439 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 142.21 NGFR rabbit IgG(H+L) / donkey NGFR 140.69
A375-B2-rep2
H8
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1111 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 143.94 NGFR rabbit IgG(H+L) / donkey NGFR 127.79
A375-B1-rep1
H8
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 845 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 127.28 NGFR rabbit IgG(H+L) / donkey NGFR 900.40
WM115-A2-rep2
H8
COLO 858 Vemurafenib 0.3160
uM
 48
hr
 2 943 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 274.12 NGFR rabbit IgG(H+L) / donkey NGFR 129.28
Colo858-B2-rep2
H8
COLO 858 Vemurafenib 0.3160
uM
 48
hr
 1 1014 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 285.27 NGFR rabbit IgG(H+L) / donkey NGFR 120.90
Colo858-B1-rep1
H8
COLO 858 Vemurafenib 0.3160
uM
 48
hr
 1 983 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 275.00 NGFR rabbit IgG(H+L) / donkey NGFR 146.13
Colo858-B2-rep1
H8
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1323 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 195.90 NGFR rabbit IgG(H+L) / donkey NGFR 165.15
A375-A2-rep2
H8
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 876 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 134.53 NGFR rabbit IgG(H+L) / donkey NGFR 1049.12
WM115-B2-rep1
H8
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1099 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 168.81 NGFR rabbit IgG(H+L) / donkey NGFR 136.50
A375-A2-rep1
H8
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 1144 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 134.31 NGFR rabbit IgG(H+L) / donkey NGFR 1008.74
WM115-B2-rep2
H8
COLO 858 Vemurafenib 0.3160
uM
 48
hr
 1 978 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 291.02 NGFR rabbit IgG(H+L) / donkey NGFR 117.92
Colo858-A2-rep1
H7
A-375 Vemurafenib 1.0000
uM
 48
hr
 2 1203 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 180.96 NGFR rabbit IgG(H+L) / donkey NGFR 155.39
A375-A2-rep2
H7
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 861 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 129.45 NGFR rabbit IgG(H+L) / donkey NGFR 1013.19
WM115-B2-rep1
H7
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 747 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 127.67 NGFR rabbit IgG(H+L) / donkey NGFR 1024.66
WM115-B1-rep2
H7
COLO 858 Vemurafenib 0.3160
uM
 48
hr
 2 1049 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 301.15 NGFR rabbit IgG(H+L) / donkey NGFR 133.13
Colo858-B2-rep2
H7
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 1020 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 135.56 NGFR rabbit IgG(H+L) / donkey NGFR 1013.45
WM115-B1-rep1
H7
COLO 858 Vemurafenib 0.3160
uM
 48
hr
 2 801 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 288.66 NGFR rabbit IgG(H+L) / donkey NGFR 159.65
Colo858-B1-rep2
H7
COLO 858 Vemurafenib 0.3160
uM
 48
hr
 1 1122 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 307.07 NGFR rabbit IgG(H+L) / donkey NGFR 147.66
Colo858-B1-rep1
H7
COLO 858 Vemurafenib 0.3160
uM
 48
hr
 1 912 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 230.07 NGFR rabbit IgG(H+L) / donkey NGFR 122.34
Colo858-B2-rep1
H7
WM-115 Vemurafenib 1.0000
uM
 48
hr
 2 810 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 133.85 NGFR rabbit IgG(H+L) / donkey NGFR 859.67
WM115-A2-rep2
H7
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1074 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 168.31 NGFR rabbit IgG(H+L) / donkey NGFR 161.00
A375-A2-rep1
H7
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 909 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 131.83 NGFR rabbit IgG(H+L) / donkey NGFR 973.88
WM115-A2-rep1
H7
COLO 858 Vemurafenib 0.3160
uM
 48
hr
 2 903 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 227.64 NGFR rabbit IgG(H+L) / donkey NGFR 138.37
Colo858-A2-rep2
H7
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 1496 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 154.86 NGFR rabbit IgG(H+L) / donkey NGFR 154.03
A375-B2-rep1
H7