Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4) - Dataset (ID:20276)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Number of Cells Primary Antibody (488) Secondary Antibody (488) Protein Detected (488) Mean Fluorescence Intensity (488) Primary Antibody (647) Secondary Antibody (647) Protein Detected (647) Mean Fluorescence Intensity (647) Plate Name Plate Well
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2542 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 186.76 NGFR rabbit IgG(H+L) / donkey NGFR 190.67
A375-B2-rep1
A6
WM-115 Vemurafenib Selisistat 1.0000 0.5333
uM
 48
hr
 1 1456 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 145.36 NGFR rabbit IgG(H+L) / donkey NGFR 1148.05
WM115-B1-rep1
C5
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2671 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 196.90 NGFR rabbit IgG(H+L) / donkey NGFR 192.72
A375-B2-rep1
A7
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2235 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 168.50 NGFR rabbit IgG(H+L) / donkey NGFR 181.65
A375-B1-rep1
A3
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2285 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 163.90 NGFR rabbit IgG(H+L) / donkey NGFR 189.57
A375-B2-rep1
A8
WM-115 Vemurafenib Vorinostat 1.0000 0.5333
uM
 48
hr
 1 1611 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 135.96 NGFR rabbit IgG(H+L) / donkey NGFR 915.06
WM115-B1-rep1
D2
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2657 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 172.03 NGFR rabbit IgG(H+L) / donkey NGFR 182.34
A375-B2-rep1
A9
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2553 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 159.96 NGFR rabbit IgG(H+L) / donkey NGFR 170.70
A375-B1-rep1
A4
A-375 Vemurafenib Olaparib 1.0000 0.1067
uM
 48
hr
 1 2585 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 174.02 NGFR rabbit IgG(H+L) / donkey NGFR 185.93
A375-B2-rep1
B2
WM-115 Vemurafenib GSK-J4 1.0000 0.5333
uM
 48
hr
 1 1681 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 133.56 NGFR rabbit IgG(H+L) / donkey NGFR 1168.38
WM115-B1-rep1
D6
A-375 Vemurafenib Iniparib 1.0000 0.1067
uM
 48
hr
 1 2591 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 168.78 NGFR rabbit IgG(H+L) / donkey NGFR 183.97
A375-B2-rep1
B3
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2318 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 158.52 NGFR rabbit IgG(H+L) / donkey NGFR 169.15
A375-B1-rep1
A5
A-375 Vemurafenib CTB 1.0000 0.1067
uM
 48
hr
 1 2800 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 161.07 NGFR rabbit IgG(H+L) / donkey NGFR 173.92
A375-B2-rep1
B4
A-375 Vemurafenib Azacitidine 1.0000 2.6667
uM
 48
hr
 1 1210 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 261.75 NGFR rabbit IgG(H+L) / donkey NGFR 53.65
A375-A2-rep1
E2
A-375 Vemurafenib Rocilinostat 1.0000 0.1067
uM
 48
hr
 1 2966 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 230.12 NGFR rabbit IgG(H+L) / donkey NGFR 190.47
A375-B2-rep1
B5
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2330 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 161.10 NGFR rabbit IgG(H+L) / donkey NGFR 180.27
A375-B1-rep1
A6
A-375 Vemurafenib GSK-J1 1.0000 0.1067
uM
 48
hr
 1 2690 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 178.62 NGFR rabbit IgG(H+L) / donkey NGFR 187.40
A375-B2-rep1
B6
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 1093 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 159.58 NGFR rabbit IgG(H+L) / donkey NGFR 1088.13
WM115-A2-rep1
A10
A-375 Vemurafenib PFI-1 1.0000 0.1067
uM
 48
hr
 1 2527 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 190.19 NGFR rabbit IgG(H+L) / donkey NGFR 218.09
A375-B2-rep1
B7
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2044 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 167.93 NGFR rabbit IgG(H+L) / donkey NGFR 183.52
A375-B1-rep1
A7
A-375 Vemurafenib UNC669 1.0000 0.1067
uM
 48
hr
 1 2260 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 166.44 NGFR rabbit IgG(H+L) / donkey NGFR 151.61
A375-B2-rep1
B8
WM-115 Vemurafenib 1.0000
uM
 48
hr
 1 1158 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 144.15 NGFR rabbit IgG(H+L) / donkey NGFR 1015.40
WM115-A2-rep1
A4
A-375 Vemurafenib Veliparib 1.0000 0.1067
uM
 48
hr
 1 2645 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 157.72 NGFR rabbit IgG(H+L) / donkey NGFR 170.56
A375-B2-rep1
C2
A-375 Vemurafenib 1.0000
uM
 48
hr
 1 2248 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 151.33 NGFR rabbit IgG(H+L) / donkey NGFR 175.00
A375-B1-rep1
A8
WM-115 Vemurafenib I-BET 1.0000 0.5333
uM
 48
hr
 1 1388 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 131.94 NGFR rabbit IgG(H+L) / donkey NGFR 759.27
WM115-B1-rep1
E7