Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 1375 734 0.1662 0.1784 0.5338 0.4970
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 1321 587 0.1903 0.1784 0.4444 0.4970
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1547 712 0.2165 0.1890 0.4602 0.4900
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1412 687 0.1880 0.1890 0.4865 0.4900
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 1315 688 0.1625 0.1890 0.5232 0.4900
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 1122 448 0.1747 0.1684 0.3993 0.4337
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 1252 538 0.1851 0.1684 0.4297 0.4337
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 1063 502 0.1454 0.1684 0.4722 0.4337
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 1466 845 0.1610 0.1825 0.5764 0.5506
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 1485 827 0.1706 0.1825 0.5569 0.5506
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 1730 897 0.2160 0.1825 0.5185 0.5506
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 1102 648 0.1177 0.1129 0.5880 0.6197
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 1095 674 0.1091 0.1129 0.6155 0.6197
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 1254 822 0.1120 0.1129 0.6555 0.6197
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1341 769 0.1483 0.1411 0.5735 0.5772
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1323 751 0.1483 0.1411 0.5676 0.5772
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 1194 705 0.1268 0.1411 0.5905 0.5772
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 1092 570 0.1353 0.1465 0.5220 0.4850
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 1147 496 0.1688 0.1465 0.4324 0.4850
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 1045 523 0.1353 0.1465 0.5005 0.4850
WM-115 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 1 4385 277 1.0230 1.0000 0.0632 0.0625
WM-115 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 2 4256 250 0.9976 1.0000 0.0587 0.0625
WM-115 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 3 4209 276 0.9794 1.0000 0.0656 0.0625
WM-115 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 1 3978 280 0.9209 0.9709 0.0704 0.0651
WM-115 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 2 4420 267 1.0342 0.9709 0.0604 0.0651