Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 1.0000
uM
 72
hr
 1 1222 950 0.0411 0.0438 0.7774 0.7578
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 1.0000
uM
 72
hr
 2 1272 891 0.0575 0.0438 0.7005 0.7578
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 1.0000
uM
 72
hr
 3 1061 844 0.0328 0.0438 0.7955 0.7578
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 1 1324 1177 0.0222 0.0219 0.8890 0.8885
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 2 1286 1129 0.0237 0.0219 0.8779 0.8885
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 3 1291 1160 0.0198 0.0219 0.8985 0.8885
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.0000
uM
 72
hr
 1 1144 810 0.0504 0.0532 0.7080 0.7386
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.0000
uM
 72
hr
 2 1388 1001 0.0584 0.0532 0.7212 0.7386
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.0000
uM
 72
hr
 3 1579 1242 0.0509 0.0532 0.7866 0.7386
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.3160
uM
 72
hr
 1 1151 927 0.0338 0.0327 0.8054 0.8107
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.3160
uM
 72
hr
 2 1128 917 0.0319 0.0327 0.8129 0.8107
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.3160
uM
 72
hr
 3 1154 939 0.0325 0.0327 0.8137 0.8107
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 1.0000
uM
 72
hr
 1 1403 1186 0.0328 0.0286 0.8453 0.8489
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 1.0000
uM
 72
hr
 2 1245 1061 0.0278 0.0286 0.8522 0.8489
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 1.0000
uM
 72
hr
 3 1107 940 0.0252 0.0286 0.8491 0.8489
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 3.1600
uM
 72
hr
 1 1231 1116 0.0174 0.0141 0.9066 0.8991
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 3.1600
uM
 72
hr
 2 759 664 0.0143 0.0141 0.8748 0.8991
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 3.1600
uM
 72
hr
 3 831 761 0.0106 0.0141 0.9158 0.8991
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 1 1254 1139 0.0174 0.0186 0.9083 0.9092
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 2 1412 1324 0.0133 0.0186 0.9377 0.9092
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 3 1402 1236 0.0251 0.0186 0.8816 0.9092
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.3160
uM
 72
hr
 1 1196 1117 0.0119 0.0098 0.9339 0.9440
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.3160
uM
 72
hr
 2 1128 1063 0.0098 0.0098 0.9424 0.9440
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.3160
uM
 72
hr
 3 1150 1099 0.0077 0.0098 0.9557 0.9440
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 1.0000
uM
 72
hr
 1 1491 1204 0.0433 0.0226 0.8075 0.8932