Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 1062 60 0.9480 1.0000 0.0565 0.0561
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 1301 83 1.1523 1.0000 0.0638 0.0561
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 999 48 0.8997 1.0000 0.0480 0.0561
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1474 97 1.3027 1.3504 0.0658 0.0554
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1474 69 1.3292 1.3504 0.0468 0.0554
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1585 85 1.4191 1.3504 0.0536 0.0554
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 950 52 0.8496 0.7364 0.0547 0.0453
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 816 40 0.7342 0.7364 0.0490 0.0453
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 683 22 0.6254 0.7364 0.0322 0.0453
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 1031 35 0.9423 0.7329 0.0339 0.0348
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 875 41 0.7890 0.7329 0.0469 0.0348
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 506 12 0.4674 0.7329 0.0237 0.0348
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 586 214 0.3519 0.3787 0.3652 0.3840
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 689 282 0.3851 0.3787 0.4093 0.3840
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 678 256 0.3992 0.3787 0.3776 0.3840
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 836 361 0.4494 0.4664 0.4318 0.4110
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 790 317 0.4475 0.4664 0.4013 0.4110
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 885 354 0.5024 0.4664 0.4000 0.4110
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 749 243 0.4787 0.3844 0.3244 0.3169
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 524 165 0.3396 0.3844 0.3149 0.3169
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 514 160 0.3349 0.3844 0.3113 0.3169
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 698 214 0.4579 0.3784 0.3066 0.3086
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 556 172 0.3633 0.3784 0.3094 0.3086
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 481 149 0.3141 0.3784 0.3098 0.3086
MMAC-SF Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 658 312 0.3273 0.3617 0.4742 0.4540