Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 1893 910 0.2305 0.2285 0.4807 0.4617
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 1289 1112 0.0415 0.0413 0.8627 0.8498
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 1083 907 0.0413 0.0413 0.8375 0.8498
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 1161 986 0.0410 0.0413 0.8493 0.8498
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1149 978 0.0401 0.0392 0.8512 0.8497
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1197 1025 0.0403 0.0392 0.8563 0.8497
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 1003 844 0.0373 0.0392 0.8415 0.8497
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 969 853 0.0272 0.0294 0.8803 0.8675
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 934 810 0.0291 0.0294 0.8672 0.8675
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 937 801 0.0319 0.0294 0.8549 0.8675
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 3961 221 0.9696 1.0000 0.0558 0.0590
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 4322 279 1.0481 1.0000 0.0646 0.0590
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 4017 228 0.9823 1.0000 0.0568 0.0590
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 3363 256 0.8055 0.8287 0.0761 0.0771
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 3395 272 0.8096 0.8287 0.0801 0.0771
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 3633 273 0.8711 0.8287 0.0751 0.0771
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 2779 239 0.6585 0.6483 0.0860 0.0808
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 2729 242 0.6447 0.6483 0.0887 0.0808
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 2655 180 0.6416 0.6483 0.0678 0.0808
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2060 182 0.4869 0.4571 0.0883 0.0908
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 1951 168 0.4622 0.4571 0.0861 0.0908
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1805 177 0.4221 0.4571 0.0981 0.0908
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 1914 546 0.3546 0.3574 0.2853 0.2896
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 1909 546 0.3534 0.3574 0.2860 0.2896
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 2000 595 0.3642 0.3574 0.2975 0.2896