Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | GR50 lower quartile | GR50 median | GR50 upper quartile | GRmax lower quartile | GRmax median | GRmax upper quartile | GRinf lower quartile | GRinf median | GRinf upper quartile | Hill Coefficient lower quartile | Hill Coefficient median | Hill Coefficient upper quartile | GR_AOC lower quartile | GR_AOC median | GR_AOC upper quartile | GEC50 lower quartile | GEC50 median | GEC50 upper quartile |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | AKT | AKT | 0.1497 | 1.0069 | 10.2321 | -0.2208 | 0.0730 | 0.3595 | -0.6783 | -0.3270 | 0.0049 | 0.3693 | 0.5173 | 0.9769 | 0.1961 | 0.3180 | 0.4712 | 0.2958 | 1.3169 | 18.2553 | |
| Sigma A6730 | AKT | AKT | 2.0327 | 6.5660 | 11.2198 | -0.9178 | -0.8320 | -0.6777 | -1.0000 | -1.0000 | -0.9546 | 0.9310 | 1.3794 | 2.0044 | 0.2439 | 0.2875 | 0.4042 | 6.3004 | 13.6236 | 19.0461 | |
| Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.9523 | 4.3787 | 11.8540 | -0.5661 | -0.3376 | -0.0359 | -1.0000 | -1.0000 | -0.4350 | 0.4858 | 0.8218 | 1.3502 | 0.1794 | 0.3014 | 0.3656 | 4.7346 | 16.5294 | 34.8041 | |
| ZM-447439 | AURK | AURK | 3.5193 | 19.1991 | 100.0000 | -0.0403 | 0.4141 | 0.5578 | -0.1176 | 0.3301 | 0.5652 | 0.5578 | 1.0337 | 2.9596 | 0.1428 | 0.2012 | 0.3024 | 0.6732 | 2.5837 | 16.4745 | |
| GSK1070916 | AURK | AURK | 0.6046 | 3.0981 | 6.6549 | -0.8474 | -0.6391 | -0.3610 | -1.0000 | -1.0000 | -0.9999 | 0.6499 | 0.9902 | 1.5949 | 0.2113 | 0.2924 | 0.4314 | 3.5405 | 8.2453 | 15.6107 | |
| NSC 663284 | CDC25 | CDC | 1.6689 | 2.2519 | 3.0742 | -0.9668 | -0.9336 | -0.8607 | -0.9846 | -0.9413 | -0.8554 | 1.8405 | 2.5456 | 4.2988 | 0.5484 | 0.5805 | 0.6318 | 2.2603 | 3.4718 | 5.7633 | |
| NU6102 | CDK1/2 | CDK | 12.2242 | 17.3275 | 31.6450 | -0.7759 | -0.4783 | -0.1439 | -1.0000 | -0.9972 | -0.6085 | 1.3221 | 1.8051 | 3.6950 | 0.1178 | 0.1554 | 0.2440 | 20.2928 | 27.4520 | 55.8294 | |
| Olomoucine II | CDK1 | CDK | 3.7444 | 6.0358 | 7.3956 | -0.7023 | -0.3927 | -0.1441 | -0.7230 | -0.4357 | -0.1137 | 1.4260 | 2.7083 | 4.7257 | 0.2563 | 0.3202 | 0.3981 | 5.9885 | 7.0813 | 8.6384 | |
| Fascaplysin | CDK4 | CDK | 0.1734 | 0.2805 | 0.3987 | -0.9809 | -0.9546 | -0.8701 | -0.9898 | -0.9538 | -0.8570 | 1.9348 | 2.3235 | 2.8230 | 0.5843 | 0.6643 | 0.7626 | 0.3281 | 0.4110 | 0.6267 | |
| Purvalanol A | CDK1 | CDK | 25.2896 | 54.7310 | 100.0000 | 0.0757 | 0.5333 | 0.7416 | -0.0675 | 0.5068 | 0.7450 | 1.0817 | 2.5000 | 4.2404 | 0.0335 | 0.0774 | 0.1767 | 18.1854 | 35.4887 | 52.3768 | |
| TCS 2312 | CHK1 | CHK | 0.3474 | 0.6156 | 0.9604 | -0.8358 | -0.6163 | -0.3941 | -0.8432 | -0.6104 | -0.3951 | 1.4081 | 2.0751 | 2.9131 | 0.3572 | 0.4368 | 0.5565 | 0.6031 | 1.0589 | 1.5099 | |
| Oxaliplatin | DNA cross-linker | DNA cross-linker | 3.2681 | 4.9333 | 12.0662 | -0.9391 | -0.8084 | -0.7104 | -1.0000 | -1.0000 | -0.9516 | 0.6228 | 0.7486 | 1.0057 | 0.4005 | 0.5419 | 0.5768 | 14.7918 | 22.6957 | 42.6124 | |
| Cisplatin | DNA cross-linker | DNA cross-linker | 4.4823 | 11.6380 | 25.2438 | -0.8850 | -0.6449 | -0.2565 | -0.9047 | -0.5931 | -0.2921 | 1.0217 | 1.3698 | 2.2177 | 0.2715 | 0.3752 | 0.4391 | 8.7984 | 21.1543 | 38.4325 | |
| Carboplatin | DNA cross-linker | DNA cross-linker | 30.4522 | 52.4276 | 91.0569 | -0.9081 | -0.7672 | -0.5844 | -0.9460 | -0.8644 | -0.7390 | 1.2433 | 1.6402 | 2.1619 | 0.2714 | 0.3706 | 0.4859 | 52.1319 | 91.7409 | 100.0000 | |
| Gemcitabine | DNA replication | DNA replication | 0.0255 | 0.1767 | 1.3221 | -0.1534 | 0.1060 | 0.2747 | -0.1430 | 0.1441 | 0.3026 | 0.5558 | 1.2204 | 2.6334 | 0.3723 | 0.5392 | 0.7460 | 0.0153 | 0.0741 | 0.2614 | |
| Afatinib | EGFR/HER2 | ErbB | 0.1253 | 1.5517 | 2.4757 | -0.9553 | -0.9200 | -0.8460 | -1.0000 | -1.0000 | -0.9391 | 0.5080 | 1.0283 | 1.7263 | 0.4620 | 0.5435 | 0.6679 | 1.1116 | 3.3143 | 4.9447 | |
| Gefitinib | EGFR | ErbB | 6.6704 | 12.9191 | 28.3915 | -0.2671 | 0.0424 | 0.3018 | -0.8465 | -0.5620 | -0.2259 | 0.9170 | 1.3719 | 2.5436 | 0.0767 | 0.1382 | 0.2408 | 9.0805 | 26.2291 | 41.5832 | |
| AG1478 | EGFR | ErbB | 8.7673 | 51.6075 | 100.0000 | -0.0710 | 0.2684 | 0.6341 | -0.3109 | -0.0273 | 0.4206 | 0.8939 | 1.7205 | 2.6373 | 0.0902 | 0.1531 | 0.2936 | 3.7212 | 36.6666 | 94.4655 | |
| Erlotinib | EGFR | ErbB | 6.4716 | 35.2468 | 100.0000 | 0.0317 | 0.4006 | 0.6354 | -0.8374 | -0.1704 | 0.3788 | 0.3155 | 0.7139 | 1.8126 | 0.0351 | 0.1228 | 0.2396 | 13.2839 | 41.2968 | 100.0000 | |
| Lapatinib | EGFR/HER2 | ErbB | 31.2806 | 100.0000 | 100.0000 | 0.4954 | 0.7950 | 0.9113 | 0.2428 | 0.7519 | 0.9066 | 0.0000 | 0.2457 | 1.3492 | 0.0247 | 0.0703 | 0.1302 | 1.5972 | 63.5403 | 100.0000 | |
| Cetuximab | EGFR | ErbB | 100.0000 | 100.0000 | 100.0000 | 0.7284 | 0.8755 | 0.9754 | 0.5964 | 0.8555 | 0.9754 | 0.0000 | 0.0000 | 0.7916 | -0.0099 | 0.0234 | 0.0674 | 3.7461 | 100.0000 | 100.0000 | |
| Valproic acid | HDAC | HDAC | 100.0000 | 100.0000 | 100.0000 | -0.8969 | -0.6820 | -0.4277 | -0.5381 | -0.3207 | -0.1180 | 1.1443 | 1.2884 | 1.4704 | 0.1935 | 0.2464 | 0.2891 | 100.0000 | 100.0000 | 100.0000 | |
| LBH589 | HDAC | HDAC | 0.0792 | 0.1432 | 0.2719 | -0.9159 | -0.8072 | -0.7128 | -0.9155 | -0.7955 | -0.6832 | 1.1720 | 1.5004 | 2.1649 | 0.5471 | 0.6739 | 0.7846 | 0.1472 | 0.2600 | 0.4626 | |
| Trichostatin A | HDAC | HDAC | 6.5374 | 11.5225 | 17.5553 | -0.9202 | -0.8512 | -0.7541 | -0.9053 | -0.8178 | -0.6756 | 1.3647 | 1.8955 | 2.2777 | 0.6490 | 0.7724 | 0.9158 | 11.0302 | 20.2024 | 30.2620 | |
| Vorinostat | HDAC | HDAC | 72.1503 | 100.0000 | 100.0000 | -0.8970 | -0.8099 | -0.5591 | -0.9320 | -0.8403 | -0.5970 | 1.0273 | 1.3201 | 1.6251 | 0.4794 | 0.5820 | 0.7389 | 100.0000 | 100.0000 | 100.0000 |