Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | Vorinostat | HDAC | HDAC | 7545.065 | uM | 113.83720 | 154.75960 | -0.9722 | -0.9704 | 3.5124 | 0.7188 | 0.9990 | 0.9803 | |
| T47DKBLUC | Unknown | Unknown | XRP44X | ELK3 | MAPK | 12608.171 | uM | 1.87240 | 1.88460 | 0.0214 | -0.0164 | 5.0000 | 0.3781 | 0.9604 | 1.0643 | |
| T47DKBLUC | Unknown | Unknown | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14628.189 | uM | 0.56230 | 0.74057 | -0.9819 | -0.9850 | 3.9529 | 0.7741 | 0.9731 | 0.7555 | |
| T47DKBLUC | Unknown | Unknown | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14182.189 | uM | 0.85314 | 1.06280 | -1.0000 | -1.0000 | 5.0000 | 0.6973 | 0.9893 | 0.3468 | |
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 12608.169 | uM | inf | inf | 0.9693 | 0.9693 | 0.0000 | 0.0194 | 0.0000 | 1.2559 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 10580.143 | uM | 22.21570 | 1000.00000 | -0.1992 | -0.8349 | 0.2580 | 0.5013 | 0.6302 | 0.8402 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 11938.143 | uM | 5.06280 | 4.72440 | -0.2303 | 0.0824 | 2.6042 | 0.4784 | 0.9191 | 0.5258 | |
| UACC-812 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 10754.143 | uM | 70.260 | 304.42490 | -0.2503 | -0.5536 | 0.5084 | 0.4129 | 0.9396 | 1.2072 | |
| UACC-812 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 10267.131 | uM | 15.31250 | 68.22830 | -0.9965 | -1.0000 | 0.7353 | 0.8841 | 0.9909 | 0.3849 | |
| UACC-812 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7926.017 | uM | 96.4740 | 365.57480 | -0.8709 | -0.9538 | 0.8012 | 0.6208 | 0.9943 | 0.8896 | |
| UACC-812 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 11938.158 | uM | 0.00298 | 0.02730 | -0.9995 | -1.0000 | 0.4957 | 1.2060 | 0.9673 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7547.066 | uM | inf | inf | 0.4999 | 0.4999 | 0.0000 | 0.2954 | 0.0619 | 0.9460 | |
| UACC-812 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 10420.066 | uM | inf | 0.03717 | 0.7876 | 0.8257 | 5.0000 | 0.0935 | 0.6066 | 0.5240 | |
| UACC-812 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 10580.141 | uM | inf | inf | 0.6310 | 0.6310 | 0.0000 | 0.1623 | 0.4808 | 0.7451 | |
| UACC-812 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 11938.158 | uM | 5.64790 | 315.35620 | 0.0953 | -1.0000 | 0.2731 | 0.2981 | 0.7328 | 0.5846 | |
| UACC-812 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 10754.153 | uM | 8.39560 | 7.49910 | 0.2161 | 0.2157 | 4.9977 | 0.0960 | 0.9733 | 1.2774 | |
| UACC-812 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 7547.072 | uM | inf | inf | 0.6965 | 0.6965 | 0.0000 | 0.2408 | -0.1290 | 0.8636 | |
| UACC-812 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 10420.072 | uM | inf | inf | 0.5919 | 0.5919 | 0.0000 | 0.1697 | 0.1494 | 0.5007 | |
| UACC-812 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 10580.072 | uM | 79.72720 | 227.48040 | 0.1478 | -1.0000 | 1.0478 | 0.1781 | 0.7889 | 0.8627 | |
| UACC-812 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 10754.072 | uM | 41.64250 | 52.2470 | -0.9864 | -0.9936 | 4.8239 | 0.1947 | 0.990 | 1.3338 | |
| UACC-812 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 14853.203 | uM | 0.00612 | 0.00710 | -0.7667 | -0.5502 | 5.0000 | 1.0796 | 0.9332 | 0.7740 | |
| UACC-812 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 14853.203 | uM | 0.00612 | 0.00710 | -0.7667 | -0.5502 | 5.0000 | 1.0796 | 0.9332 | 0.7740 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 11938.145 | uM | 1.34870 | 18.15590 | -0.4542 | -1.0000 | 0.4226 | 0.4837 | 0.7749 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 10580.145 | uM | 3.10420 | 7.39230 | -0.2758 | -0.4478 | 0.7371 | 0.3703 | 0.9136 | 0.9000 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 10754.145 | uM | 1.71970 | 2.56020 | -0.3887 | -0.3738 | 1.4028 | 0.4007 | 0.9813 | 1.0421 |