Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7892.017 | uM | 389.45810 | 1000.00000 | -0.0878 | -0.3037 | 0.5033 | 0.3259 | 0.9883 | 2.4495 | |
| BT-549 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7803.017 | uM | 238.0370 | 263.75510 | 0.0274 | -0.0295 | 0.5595 | 0.3494 | 0.9927 | 2.9572 | |
| BT-549 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7804.017 | uM | 634.7870 | 891.18150 | 0.0616 | -0.1015 | 0.5450 | 0.2855 | 0.9962 | 2.5963 | |
| BT-549 | TNBC | Basal B | 5-FU | TYMS | TYMS | 10261.131 | uM | 215.57540 | 290.46960 | -0.0136 | -0.0848 | 0.5253 | 0.3560 | 0.9881 | 2.3992 | |
| MDA-MB-231 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7893.017 | uM | 436.47320 | 1000.00000 | -0.1099 | -0.2918 | 0.5545 | 0.3222 | 0.9928 | 2.2898 | |
| MDA-MB-361 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9648.017 | uM | 73.7610 | 272.01450 | -0.9821 | -1.0000 | 0.8418 | 0.6700 | 0.9889 | 0.5727 | |
| HCC1937 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7832.017 | uM | 188.21880 | 755.07660 | -0.3109 | -0.5336 | 0.5227 | 0.4176 | 0.9972 | 1.3404 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-FU | TYMS | TYMS | 7885.017 | uM | 68.30750 | 288.83820 | -0.9570 | -1.0000 | 0.7620 | 0.6648 | 0.9889 | 0.5647 | |
| LY2 | HR+ | Luminal | 5-FU | TYMS | TYMS | 7865.017 | uM | 9.53280 | 35.8810 | -0.6181 | -0.6912 | 0.6549 | 0.8556 | 0.9694 | 1.9138 | |
| HCC1937 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7834.13 | uM | 453.5720 | 570.59710 | 0.0562 | -0.0678 | 0.5542 | 0.3087 | 0.9979 | 1.9535 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-FU | TYMS | TYMS | 7886.017 | uM | 133.62210 | 479.01180 | -0.8971 | -1.0000 | 0.8605 | 0.5873 | 0.9930 | 0.7230 | |
| MDA-MB-468 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7907.017 | uM | 127.80370 | 331.63740 | -0.5890 | -0.5993 | 0.8262 | 0.5160 | 0.9824 | 1.4157 | |
| BT-483 | HR+ | Luminal | 5-FU | TYMS | TYMS | 7801.035 | uM | 29.55510 | 200.52440 | -0.8268 | -0.9602 | 0.5598 | 0.7045 | 0.9953 | 0.5427 | |
| HCC2185 | TNBC | Luminal | 5-FU | TYMS | TYMS | 7849.017 | uM | 532.52940 | 619.620 | -0.6891 | -0.5663 | 5.0000 | 0.3976 | 0.990 | 0.3471 | |
| BT-474 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7798.017 | uM | 688.02420 | 1000.00000 | -0.1296 | -0.1902 | 0.8622 | 0.2785 | 0.9937 | 1.4161 | |
| BT-474 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9163.03 | uM | 48.43290 | 158.3510 | -0.9949 | -1.0000 | 0.9274 | 0.7288 | 0.9942 | 0.3535 | |
| HCC38 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9469.131 | uM | 492.70010 | 1000.00000 | -0.6025 | -0.6339 | 1.1567 | 0.3652 | 0.9907 | 1.0627 | |
| HCC2185 | TNBC | Luminal | 5-FU | TYMS | TYMS | 7848.017 | uM | 418.4950 | 571.66450 | -0.7572 | -0.6622 | 2.7044 | 0.4233 | 0.9935 | 0.3225 | |
| MDA-MB-453 | TNBC | Luminal | 5-FU | TYMS | TYMS | 9708.017 | uM | 83.00050 | 1000.00000 | -0.4391 | -0.8324 | 0.3938 | 0.5172 | 0.9763 | 1.0949 | |
| HCC70 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7860.017 | uM | 74.51840 | 115.49170 | -0.9988 | -0.9823 | 2.4803 | 0.8191 | 0.9927 | 0.6196 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7820.017 | uM | 127.9330 | 620.18530 | -0.7617 | -0.9506 | 0.6748 | 0.5583 | 0.9859 | 0.6915 | |
| MDA-MB-157 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7879.017 | uM | 915.45150 | 1000.00000 | 0.0233 | -0.0364 | 0.7947 | 0.2302 | 0.9921 | 1.7754 | |
| MDA-MB-453 | TNBC | Luminal | 5-FU | TYMS | TYMS | 7903.017 | uM | 119.88110 | 1000.00000 | -0.4212 | -0.7951 | 0.4487 | 0.4773 | 0.9912 | 1.1625 | |
| MDA-MB-134-VI | HR+ | Luminal | 5-FU | TYMS | TYMS | 7877.017 | uM | 1133.96240 | 1000.00000 | 0.0563 | 0.0528 | 0.8868 | 0.1924 | 0.9551 | 0.6955 | |
| MDA-MB-134-VI | HR+ | Luminal | 5-FU | TYMS | TYMS | 7876.017 | uM | 24.33680 | 434.4740 | -0.7133 | -1.0000 | 0.3812 | 0.6725 | 0.9013 | 0.6706 |