Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Triciribine | AKT | AKT | 5905.074 | uM | 0.07957 | 0.15194 | -0.2667 | -0.3062 | 0.7386 | 0.5707 | 0.9369 | 0.8648 | |
| HCC2185 | TNBC | Luminal | Triciribine | AKT | AKT | 7463.074 | uM | 0.00542 | 0.03653 | -0.6802 | -0.6973 | 0.4578 | 0.8845 | 0.9924 | 0.4574 | |
| HCC1937 | TNBC | Basal A | Triciribine | AKT | AKT | 7452.074 | uM | 11.71590 | 3.05490 | 0.4011 | 0.3068 | 0.7075 | 0.1258 | 0.9737 | 1.5162 | |
| MDA-MB-157 | TNBC | Basal B | Triciribine | AKT | AKT | 7495.074 | uM | 3.20830 | 73.02160 | 0.0644 | -1.0000 | 0.3516 | 0.2590 | 0.9067 | 1.1729 | |
| HCC70 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 12400.165 | uM | 2.21440 | 7.17070 | -0.8387 | -1.0000 | 0.9350 | 0.3886 | 0.9922 | 1.3057 | |
| HCC1806 | TNBC | Basal A | Triciribine | AKT | AKT | 7450.074 | uM | 0.07746 | 0.17066 | -0.4285 | -0.3470 | 0.6672 | 0.5284 | 0.9782 | 2.2338 | |
| Hs 578T | TNBC | Basal B | Triciribine | AKT | AKT | 7473.074 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0187 | -0.0877 | 2.5364 | |
| HCC1187 | TNBC | Basal A | Triciribine | AKT | AKT | 7431.074 | uM | 0.30781 | 0.32441 | -0.1484 | -0.1501 | 5.0000 | 0.4317 | 0.9260 | 1.4349 | |
| MDA-MB-157 | TNBC | Basal B | Triciribine | AKT | AKT | 7498.074 | uM | 1.78980 | 0.19938 | 0.4151 | 0.4073 | 0.7678 | 0.2286 | 0.9912 | 1.0877 | |
| MDA-MB-175-VII | HR+ | Luminal | Triciribine | AKT | AKT | 7500.074 | uM | 0.01816 | 0.00976 | 0.3076 | 0.4776 | 4.9998 | 0.3218 | 0.6437 | 0.5279 | |
| HCC1395 | TNBC | Basal B | Triciribine | AKT | AKT | 7435.074 | uM | 1.38020 | 37.05640 | 0.1032 | -0.8302 | 0.2974 | 0.3180 | 0.9201 | 0.8579 | |
| HCC2185 | TNBC | Luminal | Sigma A6730 | AKT | AKT | 10996.153 | uM | 0.80696 | 1.86130 | -0.9987 | -0.9947 | 1.3103 | 0.6148 | 0.9761 | 0.3186 | |
| HCC38 | TNBC | Basal B | Triciribine | AKT | AKT | 7469.074 | uM | 1.93740 | 2.47520 | 0.0995 | -0.0812 | 0.6143 | 0.2290 | 0.9851 | 1.9843 | |
| HCC38 | TNBC | Basal B | Triciribine | AKT | AKT | 7468.074 | uM | 0.29265 | 0.28992 | 0.0167 | 0.0229 | 5.0000 | 0.4113 | 0.8951 | 1.5027 | |
| HCC1806 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 12239.165 | uM | 9.67380 | 17.26610 | -0.8465 | -0.9909 | 1.8858 | 0.2211 | 0.9992 | 2.0705 | |
| MDA-MB-134-VI | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10998.153 | uM | 7.28970 | 15.73960 | -0.9847 | -1.0000 | 1.4273 | 0.3349 | 0.9248 | 0.7434 | |
| MDA-MB-134-VI | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10519.141 | uM | 10.01420 | 17.01780 | -0.9832 | -1.0000 | 2.0719 | 0.2793 | 0.9732 | 1.0417 | |
| AU565 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 10880.153 | uM | 2.73280 | 8.96010 | -0.8497 | -1.0000 | 0.9252 | 0.4067 | 0.9538 | 1.6896 | |
| MDA-MB-134-VI | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12206.158 | uM | 11.50920 | 17.9770 | -0.9531 | -1.0000 | 2.4636 | 0.2873 | 0.9735 | 1.1431 | |
| HCC2185 | TNBC | Luminal | Sigma A6730 | AKT | AKT | 12192.158 | uM | 2.37830 | 7.77320 | -0.7569 | -1.0000 | 0.9276 | 0.3892 | 0.9796 | 0.6680 | |
| BT-483 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 11855.158 | uM | 0.14373 | 3.28620 | -0.6376 | -1.0000 | 0.3511 | 0.6088 | 0.9430 | 0.6941 | |
| HCC2185 | TNBC | Luminal | Triciribine | AKT | AKT | 7462.074 | uM | 0.01558 | 0.06147 | -0.2375 | -0.4011 | 0.4292 | 0.6971 | 0.8823 | 0.6126 | |
| MDA-MB-134-VI | HR+ | Luminal | Triciribine | AKT | AKT | 7494.074 | uM | 0.43155 | 0.25258 | 0.2066 | 0.1165 | 0.4950 | 0.3473 | 0.9907 | 0.6767 | |
| MDA-MB-157 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 12594.165 | uM | 14.42930 | 18.00520 | -0.9472 | -0.9508 | 4.8113 | 0.1719 | 0.9959 | 1.4798 | |
| 600MPE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12224.165 | uM | 6.5660 | 13.29760 | -0.9371 | -1.0000 | 1.5568 | 0.3611 | 0.9610 | 0.9714 |