Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | Sigma A6730 | AKT | AKT | 12509.165 | uM | 3.14240 | 13.05610 | -0.6553 | -1.0000 | 0.7714 | 0.3161 | 0.9885 | 1.5022 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10755.153 | uM | 10.12190 | 11.78250 | -0.5684 | -0.5687 | 5.0000 | 0.2778 | 0.9603 | 0.7471 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 5894.074 | uM | 0.10268 | 0.28489 | -0.6622 | -0.6112 | 0.7825 | 0.5807 | 0.9866 | 1.4541 | |
| HCC1806 | TNBC | Basal A | Triciribine | AKT | AKT | 7450.074 | uM | 0.07746 | 0.17066 | -0.4285 | -0.3470 | 0.6672 | 0.5284 | 0.9782 | 2.2338 | |
| 184B5 | NM | Basal | Sigma A6730 | AKT | AKT | 12566.165 | uM | 2.97380 | 8.22950 | -0.8497 | -1.0000 | 1.0793 | 0.4028 | 0.9697 | 1.7248 | |
| HCC1937 | TNBC | Basal A | Triciribine | AKT | AKT | 7452.074 | uM | 11.71590 | 3.05490 | 0.4011 | 0.3068 | 0.7075 | 0.1258 | 0.9737 | 1.5162 | |
| BT-483 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10696.153 | uM | 1.1750 | 2.84060 | -0.6524 | -0.6846 | 0.9772 | 0.4348 | 0.9803 | 0.5484 | |
| BT-483 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 11855.158 | uM | 0.14373 | 3.28620 | -0.6376 | -1.0000 | 0.3511 | 0.6088 | 0.9430 | 0.6941 | |
| 184B5 | NM | Basal | Triciribine | AKT | AKT | 5897.074 | uM | 0.14593 | 0.26720 | -0.6810 | -0.6218 | 1.3360 | 0.6294 | 0.9925 | 1.2824 | |
| HCC202 | HER2amp | Luminal | Triciribine | AKT | AKT | 7458.074 | uM | 0.02409 | 0.04816 | -0.9605 | -0.8085 | 1.3885 | 0.9029 | 0.9881 | 0.4138 | |
| BT-483 | HR+ | Luminal | Triciribine | AKT | AKT | 5908.074 | uM | 0.01754 | 0.14176 | -0.3535 | -0.5337 | 0.3476 | 0.6743 | 0.9586 | 0.5224 | |
| 184B5 | NM | Basal | Triciribine | AKT | AKT | 5896.074 | uM | 0.08583 | 0.37083 | -0.6648 | -0.7348 | 0.6178 | 0.6095 | 0.9963 | 1.4124 | |
| 600MPE | HR+ | Luminal | Triciribine | AKT | AKT | 5899.074 | uM | 0.63713 | 68.74810 | 0.0341 | -1.0000 | 0.2347 | 0.3748 | 0.9523 | 0.8860 | |
| AU565 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 10880.153 | uM | 2.73280 | 8.96010 | -0.8497 | -1.0000 | 0.9252 | 0.4067 | 0.9538 | 1.6896 | |
| CAMA-1 | HR+ | Luminal | Triciribine | AKT | AKT | 5911.074 | uM | 0.71750 | 77.1850 | 0.0662 | -1.0000 | 0.2348 | 0.3781 | 0.9378 | 1.1317 | |
| CAMA-1 | HR+ | Luminal | Triciribine | AKT | AKT | 5912.074 | uM | 1.78230 | 4.31760 | 0.1350 | -0.2496 | 0.4577 | 0.2801 | 0.9575 | 0.9249 | |
| BT-549 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 12305.165 | uM | 12.39490 | 20.55540 | -0.8811 | -1.0000 | 2.1719 | 0.2542 | 0.9818 | 2.7020 | |
| BT-20 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10581.141 | uM | 5.68520 | 11.73980 | -0.9996 | -1.0000 | 1.5151 | 0.3224 | 0.9843 | 0.6310 | |
| BT-20 | TNBC | Basal A | Triciribine | AKT | AKT | 5902.074 | uM | 1.97260 | 8.09640 | -0.2309 | -0.7316 | 0.6384 | 0.2588 | 0.9950 | 1.2939 | |
| BT-20 | TNBC | Basal A | Triciribine | AKT | AKT | 5903.074 | uM | 1.02210 | 3.13290 | -0.3635 | -0.6039 | 0.7071 | 0.3330 | 0.9862 | 1.0729 | |
| AU565 | HER2amp | Luminal | Triciribine | AKT | AKT | 5900.074 | uM | 0.07721 | 0.15941 | -0.5051 | -0.5223 | 0.9865 | 0.6448 | 0.9219 | 2.4189 | |
| AU565 | HER2amp | Luminal | Triciribine | AKT | AKT | 5901.074 | uM | 0.02039 | 0.16902 | -0.8539 | -0.9086 | 0.4897 | 0.7799 | 0.9864 | 1.8718 | |
| BT-549 | TNBC | Basal B | Triciribine | AKT | AKT | 5909.074 | uM | inf | inf | 0.8037 | 0.8037 | 0.0000 | 0.1765 | 0.3969 | 2.8598 | |
| HCC3153 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10937.153 | uM | 12.10530 | 19.95720 | -0.8966 | -1.0000 | 2.1975 | 0.2508 | 0.9836 | 1.5187 | |
| HCC3153 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10577.141 | uM | 8.0270 | 56.07330 | -0.0634 | -1.0000 | 0.5652 | 0.2508 | 0.9124 | 0.9203 |