Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Triciribine | AKT | AKT | 5903.074 | uM | 1.02210 | 3.13290 | -0.3635 | -0.6039 | 0.7071 | 0.3330 | 0.9862 | 1.0729 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 12000.165 | uM | 3.01750 | 8.41350 | -0.9985 | -1.0000 | 1.0714 | 0.3839 | 0.9739 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 12084.158 | uM | 9.55270 | 16.05570 | -0.9851 | -1.0000 | 2.1158 | 0.2902 | 0.9749 | 1.2976 | |
| HCC1395 | TNBC | Basal B | Triciribine | AKT | AKT | 7435.074 | uM | 1.38020 | 37.05640 | 0.1032 | -0.8302 | 0.2974 | 0.3180 | 0.9201 | 0.8579 | |
| HCC1419 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12001.165 | uM | 0.81605 | 3.11870 | -0.9607 | -1.0000 | 0.8194 | 0.5612 | 0.9606 | 0.5382 | |
| BT-20 | TNBC | Basal A | Triciribine | AKT | AKT | 5904.074 | uM | 0.56544 | 0.77026 | -0.2190 | -0.1688 | 0.9408 | 0.3518 | 0.9569 | 0.9654 | |
| BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12056.158 | uM | 0.72952 | 3.1890 | -0.8607 | -1.0000 | 0.7448 | 0.5557 | 0.9726 | 0.9929 | |
| AU565 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 10880.153 | uM | 2.73280 | 8.96010 | -0.8497 | -1.0000 | 0.9252 | 0.4067 | 0.9538 | 1.6896 | |
| 184B5 | NM | Basal | Sigma A6730 | AKT | AKT | 12566.165 | uM | 2.97380 | 8.22950 | -0.8497 | -1.0000 | 1.0793 | 0.4028 | 0.9697 | 1.7248 | |
| 184A1 | NM | Basal | Sigma A6730 | AKT | AKT | 12509.165 | uM | 3.14240 | 13.05610 | -0.6553 | -1.0000 | 0.7714 | 0.3161 | 0.9885 | 1.5022 | |
| 184B5 | NM | Basal | Triciribine | AKT | AKT | 5897.074 | uM | 0.14593 | 0.26720 | -0.6810 | -0.6218 | 1.3360 | 0.6294 | 0.9925 | 1.2824 | |
| 184B5 | NM | Basal | Triciribine | AKT | AKT | 5896.074 | uM | 0.08583 | 0.37083 | -0.6648 | -0.7348 | 0.6178 | 0.6095 | 0.9963 | 1.4124 | |
| AU565 | HER2amp | Luminal | Triciribine | AKT | AKT | 5900.074 | uM | 0.07721 | 0.15941 | -0.5051 | -0.5223 | 0.9865 | 0.6448 | 0.9219 | 2.4189 | |
| 600MPE | HR+ | Luminal | Triciribine | AKT | AKT | 5899.074 | uM | 0.63713 | 68.74810 | 0.0341 | -1.0000 | 0.2347 | 0.3748 | 0.9523 | 0.8860 | |
| 600MPE | HR+ | Luminal | Triciribine | AKT | AKT | 5898.074 | uM | 0.57767 | 3.96870 | -0.0423 | -0.5354 | 0.3777 | 0.3788 | 0.9668 | 0.7134 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 5894.074 | uM | 0.10268 | 0.28489 | -0.6622 | -0.6112 | 0.7825 | 0.5807 | 0.9866 | 1.4541 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 5895.074 | uM | 0.08792 | 0.23992 | -0.7686 | -0.7129 | 0.8827 | 0.6419 | 0.9956 | 1.1218 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10755.153 | uM | 10.12190 | 11.78250 | -0.5684 | -0.5687 | 5.0000 | 0.2778 | 0.9603 | 0.7471 | |
| CAMA-1 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12070.158 | uM | 2.60090 | 7.86290 | -0.8870 | -1.0000 | 0.9931 | 0.3840 | 0.9790 | 1.1252 | |
| 600MPE | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12224.165 | uM | 6.5660 | 13.29760 | -0.9371 | -1.0000 | 1.5568 | 0.3611 | 0.9610 | 0.9714 | |
| BT-20 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10581.141 | uM | 5.68520 | 11.73980 | -0.9996 | -1.0000 | 1.5151 | 0.3224 | 0.9843 | 0.6310 | |
| BT-20 | TNBC | Basal A | Triciribine | AKT | AKT | 5902.074 | uM | 1.97260 | 8.09640 | -0.2309 | -0.7316 | 0.6384 | 0.2588 | 0.9950 | 1.2939 | |
| BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12178.158 | uM | 1.57950 | 4.28540 | -0.8896 | -1.0000 | 1.1007 | 0.4947 | 0.9798 | 0.7379 | |
| HCC1428 | HR+ | Luminal | Triciribine | AKT | AKT | 7441.074 | uM | 0.06776 | 0.79166 | -0.7654 | -1.0000 | 0.4469 | 0.6528 | 0.9650 | 0.8339 | |
| HCC1428 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10693.153 | uM | 3.63940 | 9.60190 | -0.9834 | -1.0000 | 1.1324 | 0.3920 | 0.9640 | 0.8137 |