Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9035.001 | uM | 3.31290 | 213.70830 | 0.1236 | -1.0000 | 0.2637 | 0.2641 | 0.8354 | 2.4291 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11854.16 | uM | inf | 0.18692 | 0.5222 | 0.5463 | 1.7992 | 0.1850 | 0.9584 | 1.3102 | |
| HCC2185 | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10996.15 | uM | 0.22479 | 0.19030 | 0.0203 | 0.1302 | 1.8105 | 0.3260 | 0.9140 | 0.5092 | |
| CAMA-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10755.15 | uM | inf | inf | 0.2169 | 0.2169 | 0.0000 | 0.2802 | 0.2284 | 0.7807 | |
| HCC38 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11850.16 | uM | 0.16510 | 0.47277 | -0.5340 | -0.4837 | 0.6432 | 0.4725 | 0.9405 | 1.8797 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9254.001 | uM | 5.38610 | 6.70950 | -1.0000 | -0.9998 | 5.0000 | 0.3079 | 0.9082 | 0.3986 | |
| AU565 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9146.001 | uM | 2.55360 | 9.30180 | -0.6291 | -1.0000 | 0.8499 | 0.3663 | 0.8348 | 1.2878 | |
| 184A1 | NM | Basal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12509.169 | uM | 2.47570 | 23.78060 | -0.3199 | -1.0000 | 0.4856 | 0.3696 | 0.9823 | 1.5064 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 10002.001 | uM | 0.64737 | 2.67080 | -0.5505 | -0.8031 | 0.6759 | 0.3916 | 0.9922 | 0.5372 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7853.001 | uM | 8.20720 | 30.58260 | -0.0642 | -1.0000 | 0.8352 | 0.1798 | 0.9652 | 1.5775 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10816.15 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.3031 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 10056.001 | uM | 12.78590 | 52.63390 | 0.1678 | -1.0000 | 0.7764 | 0.1357 | 0.9744 | 0.9052 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 9186.001 | uM | 4.77160 | 14.99120 | -0.3723 | -1.0000 | 0.9597 | 0.2294 | 0.9503 | 0.5165 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7821.001 | uM | 5.54660 | 6.28550 | -0.4340 | -0.4344 | 4.9999 | 0.1813 | 0.9787 | 0.3296 | |
| 184A1 | NM | Basal | GSK1070916 | AURK | AURK | 9047.001 | uM | 0.83697 | 5.25260 | -0.4457 | -0.9735 | 0.5885 | 0.3812 | 0.9828 | 0.7701 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 7849.001 | uM | 0.52517 | 4.12770 | -0.6199 | -1.0000 | 0.5329 | 0.4275 | 0.9620 | 0.5308 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12000.169 | uM | 2.54270 | 8.67140 | -0.9866 | -1.0000 | 0.8955 | 0.4942 | 0.9205 | 0.8565 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10873.15 | uM | 1.14590 | 0.89832 | 0.1529 | 0.2620 | 3.0488 | 0.1976 | 0.9686 | 1.1958 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 10263.001 | uM | 0.14569 | 3.45390 | -0.4750 | -1.0000 | 0.3470 | 0.5409 | 0.8338 | 0.3258 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10473.138 | uM | inf | 0.52667 | 0.7059 | 0.7725 | 1.9365 | 0.1088 | 0.7415 | 1.2872 | |
| 184B5 | NM | Basal | ZM-447439 | AURK | AURK | 12566.169 | uM | inf | 0.69572 | 0.6262 | 0.6434 | 1.3748 | 0.1369 | 0.9197 | 1.6359 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 9420.001 | uM | 0.03883 | 0.83363 | -0.8630 | -1.0000 | 0.3583 | 0.6662 | 0.8579 | 0.3332 | |
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 9210.001 | uM | 8.02190 | 17.5930 | -0.4354 | -1.0000 | 1.3989 | 0.2132 | 0.9502 | 0.8761 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 7848.001 | uM | 0.23168 | 2.21180 | -0.7395 | -1.0000 | 0.4869 | 0.5192 | 0.9120 | 0.4548 | |
| HCC2185 | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12192.16 | uM | 0.35927 | 0.12565 | 0.2935 | 0.3575 | 1.1951 | 0.2654 | 0.8281 | 0.7363 |