Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Taxol | TUBB | TUBB | 9420.002 | uM | 0.00674 | 0.00772 | -0.4979 | -0.4884 | 5.0000 | 0.9765 | 0.9936 | 0.3242 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 9420.002 | uM | 0.00221 | 0.00307 | -0.3921 | -0.4272 | 1.8972 | 0.9033 | 0.9915 | 0.3242 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 10150.001 | uM | 0.00995 | 0.01171 | -0.5826 | -0.6272 | 5.0000 | 0.9813 | 0.9937 | 0.3255 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 10150.001 | uM | 3.88470 | 13.45150 | -0.5015 | -1.0000 | 0.8845 | 0.2772 | 0.8331 | 0.3255 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10150.001 | uM | 11.48630 | 14.5110 | -0.9569 | -0.9966 | 4.6902 | 0.2332 | 0.7847 | 0.3255 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 10263.001 | uM | 0.03162 | 0.03969 | -0.5522 | -0.6572 | 3.6909 | 0.9431 | 0.9385 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 10263.001 | uM | 0.00423 | 0.00507 | -0.9767 | -0.7367 | 5.0000 | 1.1583 | 0.9733 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 10263.001 | uM | 0.14569 | 3.45390 | -0.4750 | -1.0000 | 0.3470 | 0.5409 | 0.8338 | 0.3258 | |
| HCC38 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10268.12 | uM | 0.41958 | 0.88930 | -1.0000 | -0.9927 | 1.4560 | 1.1119 | 0.9972 | 0.3272 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10268.12 | uM | 0.00161 | 0.00201 | -0.9994 | -1.0000 | 5.0000 | 1.6132 | 0.9985 | 0.3272 | |
| HCC38 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10268.12 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 1.2668 | 0.5308 | 0.3272 | |
| HCC2185 | TNBC | Luminal | AG1478 | EGFR | ErbB | 7846.016 | uM | 3.19930 | 11.74650 | -0.5650 | -0.7419 | 0.6995 | 0.4549 | 0.7873 | 0.3279 | |
| HCC2185 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 7846.016 | uM | 8.07560 | 13.51120 | -0.7529 | -1.0000 | 2.1346 | 0.2060 | 0.9492 | 0.3279 | |
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7846.016 | uM | 6.79370 | 6.48310 | -0.3064 | 0.1043 | 5.0000 | 0.3414 | 0.5784 | 0.3279 | ||
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7821.001 | uM | 0.70071 | 8.29840 | -0.6547 | -1.0000 | 0.4445 | 0.3641 | 0.7623 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7821.001 | uM | 5.54660 | 6.28550 | -0.4340 | -0.4344 | 4.9999 | 0.1813 | 0.9787 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7821.001 | uM | 6.66610 | 8.08760 | -0.8039 | -0.8055 | 4.9650 | 0.2362 | 0.8982 | 0.3296 | |
| HCC202 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 10470.072 | uM | 55.75220 | 80.06650 | -0.8066 | -1.0000 | 3.0353 | 0.1418 | 0.9823 | 0.3299 | |
| HCC70 | TNBC | Basal A | Nelfinavir | 12714.174 | uM | 8.95410 | 11.15450 | -1.0000 | -1.0000 | 5.0000 | 0.3201 | 0.8734 | 0.3306 | |||
| HCC70 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 12714.174 | uM | inf | inf | 1.0210 | 1.0210 | 0.0000 | 0.2086 | 0.0000 | 0.3306 | |
| HCC70 | TNBC | Basal A | Mebendazole | 12714.174 | uM | 0.11165 | 0.17592 | -0.9403 | -0.8934 | 2.2542 | 1.0180 | 0.9090 | 0.3306 | |||
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9420.132 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0075 | -0.0001 | 0.3309 | ||
| HCC2185 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 9420.132 | uM | inf | inf | 0.4783 | 0.4783 | 0.0000 | 0.1427 | 0.1330 | 0.3309 | |
| UACC-893 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9933.021 | uM | 67.82910 | 84.49720 | -0.9980 | -1.0000 | 4.9999 | 0.2854 | 0.7469 | 0.3311 | |
| UACC-893 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9933.021 | uM | 548.04560 | 682.71740 | -0.9560 | -1.0000 | 5.0000 | 0.1249 | 0.9516 | 0.3311 |