Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-893 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9933.001 | uM | 7.66590 | 31.25820 | -0.0485 | -1.0000 | 0.7817 | 0.1942 | 0.8542 | 0.4544 | |
| LY2 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10816.149 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0238 | -0.1642 | 0.4545 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10816.149 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.4545 | |
| BT-483 | HR+ | Luminal | AG1024 | IGF1R | RTK | 5908.066 | uM | inf | inf | 0.0534 | 0.0534 | 0.0000 | 0.3542 | 0.4565 | 0.4546 | |
| BT-483 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 5908.066 | uM | 1.75580 | 21.91120 | -0.4730 | -1.0000 | 0.4353 | 0.4147 | 0.7753 | 0.4546 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 7848.001 | uM | 0.00690 | 0.01004 | -0.7963 | -0.4889 | 1.8144 | 0.9258 | 0.9490 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 7848.001 | uM | 0.23168 | 2.21180 | -0.7395 | -1.0000 | 0.4869 | 0.5192 | 0.9120 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 7848.001 | uM | 0.06638 | 0.07453 | -0.5258 | -0.3922 | 5.0000 | 0.6420 | 0.9828 | 0.4548 | |
| HCC1395 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 13538.176 | uM | inf | inf | 0.8042 | 0.8042 | 0.0000 | 0.1436 | 0.3146 | 0.4572 | |
| HCC2185 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7463.074 | uM | 0.01945 | 0.03339 | -0.9295 | -0.8410 | 1.8261 | 1.2121 | 0.9953 | 0.4574 | |
| HCC2185 | TNBC | Luminal | Triciribine | AKT | AKT | 7463.074 | uM | 0.00542 | 0.03653 | -0.6802 | -0.6973 | 0.4578 | 0.8845 | 0.9924 | 0.4574 | |
| HCC2185 | TNBC | Luminal | Etoposide | TOP2 | TOP | 7463.074 | uM | 42.50860 | 61.23060 | -0.3217 | -0.4060 | 1.6287 | 0.2813 | 0.8396 | 0.4574 | |
| HCC2185 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7463.074 | uM | 0.01945 | 0.03339 | -0.9295 | -0.8410 | 1.8261 | 1.2121 | 0.9953 | 0.4574 | |
| MDA-MB-175-VII | HR+ | Luminal | Gefitinib | EGFR | ErbB | 7884.016 | uM | 0.47631 | 0.73937 | -0.9300 | -0.8658 | 2.2852 | 0.5216 | 0.9965 | 0.4603 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 7884.016 | uM | 0.94029 | 1.49620 | -0.9477 | -0.9023 | 2.2201 | 0.6875 | 0.9970 | 0.4603 | |
| MDA-MB-175-VII | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7884.016 | uM | inf | inf | 1.0238 | 1.0238 | 0.0000 | -0.0464 | -32.8843 | 0.4603 | ||
| UACC-812 | HER2amp | Luminal | Trametinib | MEK | MAPK | 10150.012 | uM | 19.17560 | 17.90770 | 0.6457 | 0.1448 | 5.0000 | 0.0038 | 0.7810 | 0.4611 | |
| UACC-812 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 10150.012 | uM | 0.02042 | 0.02445 | -0.7512 | -0.7308 | 4.9997 | 1.1335 | 0.9985 | 0.4611 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 7811.036 | uM | 4.20720 | 17.31660 | 0.0126 | -1.0000 | 0.7765 | 0.1581 | 0.9649 | 0.4612 | |
| HCC1395 | TNBC | Basal B | Mebendazole | 13538.174 | uM | 0.35354 | 3.4640 | -0.6961 | -1.0000 | 0.4814 | 0.5295 | 0.9154 | 0.4615 | |||
| HCC1395 | TNBC | Basal B | Nelfinavir | 13538.174 | uM | 27.72930 | 47.49070 | 0.3603 | -0.9028 | 1.9173 | 0.0735 | 0.9481 | 0.4615 | |||
| HCC1395 | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 13538.174 | uM | inf | 0.14414 | 0.6866 | 0.6441 | 5.0000 | 0.1678 | 0.7406 | 0.4615 | |
| HCC1419 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 7437.073 | uM | 146.82210 | 170.80150 | 0.2612 | -0.5653 | 5.0000 | 0.0246 | 0.9617 | 0.4617 | |
| MDA-MB-175-VII | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7500.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0333 | -0.7066 | 0.4619 | |
| MDA-MB-175-VII | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7500.095 | uM | 0.01082 | 0.57770 | -0.9986 | -1.0000 | 0.2762 | 0.7708 | 0.6111 | 0.4619 |