Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MDA-MB-415
HR+
Luminal
 17-AAG
HSP90
HSP90
9664.037
uM
0.09572
0.11439
 -0.9995 -0.7190 5.0000 0.8937
0.9660
 0.7953
MDA-MB-361
HER2amp
Luminal
 Valproic acid
HDAC
HDAC
12379.143
uM
450.79670
972.52820
 -0.9995 -1.0000 1.4288 0.4119
0.9965
 0.4493
600MPE
HR+
Luminal
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
5899.067
uM
2.37830
4.93120
 -0.9995 -1.0000 1.5066 0.6079
0.9889
 0.9897
HCC202
HER2amp
Luminal
 Trichostatin A
HDAC
HDAC
7458.065
uM
0.92043
1.63230
 -0.9995 -1.0000 1.9177 1.2766
0.9965
 0.4917
HCC1395
TNBC
Basal B
 Methylglyoxal
13165.184
uM
488.01040
1000.00000
 -0.9995 -0.7261 1.2503 0.4988
0.9358
 0.5940
LY2
HR+
Luminal
 Trichostatin A
HDAC
HDAC
7477.065
uM
6.29540
8.97720
 -0.9995 -0.9667 3.0326 0.9357
0.9982
 0.7891
BT-483
HR+
Luminal
 Temsirolimus
MTOR
MTOR
11855.144
uM
0.00173
0.54075
 -0.9995 -1.0000 0.1912 0.9073
0.6959
 0.5961
MDA-MB-361
HER2amp
Luminal
 Doxorubicin
TOP2
TOP
9648.121
uM
0.11428
0.13646
 -0.9995 -0.7141 5.0000 0.8762
0.9561
 0.6537
MDA-MB-361
HER2amp
Luminal
 Epirubicin
TOP2
TOP
7896.017
uM
0.25479
0.30463
 -0.9995 -0.7217 5.0000 0.8046
0.9647
 1.0113
UACC-812
HER2amp
Luminal
 Afatinib
EGFR/HER2
ErbB
11938.158
uM
0.00298
0.02730
 -0.9995 -1.0000 0.4957 1.2060
0.9673
 0.5846
LY2
HR+
Luminal
 Vorinostat
HDAC
HDAC
7477.065
uM
164.46940
242.89610
 -0.9995 -0.9975 2.8133 0.6664
0.9940
 0.7891
600MPE
HR+
Luminal
 Imatinib
ABL/KIT/PDGFR
nRTK
5898.091
uM
24.51260
30.53630
 -0.9995 -1.0000 4.9997 0.4350
0.9907
 0.6159
HCC1395
TNBC
Basal B
 GSK461364
PLK1
PLK
7813.001
uM
0.01050
0.01379
 -0.9995 -0.5491 2.7174 0.8875
0.9467
 0.7338
MDA-MB-361
HER2amp
Luminal
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
7508.067
uM
9.14220
11.38870
 -0.9994 -1.0000 5.0000 0.4106
0.9941
 0.7560
MDA-MB-175-VII
HR+
Luminal
 ZM-447439
AURK
AURK
10642.138
uM
19.16960
29.1850
 -0.9994 -1.0000 2.6137 0.4105
0.7449
 0.5620
MX1
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
14918.203
uM
0.00872
0.01466
 -0.9994 -0.9980 2.1115 1.3233
0.9984
 0.5296
SUM1315MO2
TNBC
Basal B
 Bortezomib
Proteasome
Proteasome
9044.074
uM
0.03803
0.06612
 -0.9994 -0.9731 1.9532 1.1764
0.9971
 0.6607
HCC38
TNBC
Basal B
 Gemcitabine
DNA replication
DNA replication
10268.12
uM
0.00161
0.00201
 -0.9994 -1.0000 5.0000 1.6132
0.9985
 0.3272
MX1
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
14918.203
uM
0.00872
0.01466
 -0.9994 -0.9980 2.1115 1.3233
0.9984
 0.5296
BT-474
HER2amp
Luminal
 GSK461364
PLK1
PLK
9163.001
uM
inf
inf
 -0.9994 -0.9994 0.0000 0.4623
0.5005
 0.5227
BT-474
HER2amp
Luminal
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
12178.154
uM
0.27381
1.07140
 -0.9994 -1.0000 0.8053 0.5291
0.9912
 0.5170
HCC1428
HR+
Luminal
 Epirubicin
TOP2
TOP
9294.017
uM
1.25510
1.74180
 -0.9994 -0.9690 3.2891 0.6721
0.9982
 0.8160
UACC-812
HER2amp
Luminal
 IKK16
IKK
NFKB
10420.093
uM
4.17050
5.19540
 -0.9994 -1.0000 5.0000 0.4914
0.9287
 0.5629
UACC-812
HER2amp
Luminal
 CGC-11047
Polyamine analogue
10267.026
uM
15.170
207.56150
 -0.9994 -1.0000 0.4199 0.5813
0.7864
 0.3125
SUM52PE
HR+
Luminal
 CGC-11047
Polyamine analogue
7923.018
uM
0.15750
6.39610
 -0.9994 -1.0000 0.2966 1.0403
0.7812
 0.7947