Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7844.001 | uM | inf | inf | -0.9997 | -0.9997 | 0.0000 | 0.8273 | 0.4411 | 0.3060 | |
| SUM52PE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7540.078 | uM | 0.12817 | 0.16578 | -0.9997 | -0.8307 | 3.8038 | 0.8677 | 0.9932 | 0.9523 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 7534.084 | uM | 0.03012 | 0.08208 | -0.9997 | -1.0000 | 1.0956 | 0.9283 | 0.9950 | 0.8905 | |
| BT-20 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10581.141 | uM | 5.68520 | 11.73980 | -0.9996 | -1.0000 | 1.5151 | 0.3224 | 0.9843 | 0.6310 | |
| MDA-MB-175-VII | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10818.144 | uM | 0.01641 | 2.00290 | -0.9996 | -1.0000 | 0.2287 | 0.7745 | 0.7471 | 0.4912 | |
| MDA-MB-175-VII | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7500.067 | uM | 8.01910 | 9.98970 | -0.9996 | -1.0000 | 4.9998 | 0.4013 | 0.9914 | 0.7143 | |
| BT-474 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9163.024 | uM | 0.70741 | 1.59310 | -0.9996 | -1.0000 | 1.3532 | 0.6048 | 0.7473 | 0.5524 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 9777.001 | uM | 2.45790 | 5.23750 | -0.9996 | -1.0000 | 1.4522 | 0.3113 | 0.9764 | 0.7223 | |
| MDA-MB-361 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 10472.1 | uM | 0.61567 | 3.65480 | -0.9996 | -1.0000 | 0.6168 | 0.5186 | 0.9414 | 0.6324 | |
| MDA-MB-157 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 10093.001 | uM | 0.00477 | 0.00590 | -0.9996 | -0.9361 | 5.0000 | 1.3152 | 0.9914 | 0.5759 | |
| 184A1 | NM | Basal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9047.011 | uM | 0.53932 | 2.18460 | -0.9996 | -1.0000 | 0.7854 | 0.8887 | 0.9928 | 0.6293 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10470.087 | uM | 0.00098 | 0.00256 | -0.9996 | -1.0000 | 1.1390 | 1.4830 | 0.9905 | 0.3641 | |
| MDA-MB-415 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10938.153 | uM | 8.03970 | 10.01450 | -0.9996 | -0.9994 | 5.0000 | 0.3668 | 0.9294 | 0.4228 | |
| HCC3153 | TNBC | Basal A | Nelfinavir | 12939.174 | uM | 2.09890 | 5.54180 | -0.9996 | -1.0000 | 1.1315 | 0.4041 | 0.9209 | 0.3466 | |||
| MX1 | Unknown | Unknown | SB-3CT | MMP2/9 | MMP | 12220.144 | uM | 0.21073 | 1.6780 | -0.9996 | -1.0000 | 0.5295 | 0.7991 | 0.7647 | 0.5126 | |
| HCC2185 | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7464.095 | uM | inf | inf | -0.9996 | -0.9996 | 0.0000 | 0.6542 | 0.4315 | 0.5464 | |
| HCC1428 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7444.067 | uM | 5.56940 | 8.47330 | -0.9996 | -1.0000 | 2.6181 | 0.4675 | 0.9936 | 0.7382 | |
| ZR-75-1 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9958.021 | uM | 2.61520 | 8.32030 | -0.9996 | -1.0000 | 0.9493 | 0.6504 | 0.9645 | 0.5129 | |
| UACC-812 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10150.021 | uM | 2.16490 | 4.71260 | -0.9996 | -0.9075 | 1.3305 | 0.7126 | 0.9610 | 0.4883 | |
| UACC-812 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10151.021 | uM | 7.84270 | 16.49440 | -0.9996 | -0.9978 | 1.4758 | 0.6545 | 0.9947 | 0.3048 | |
| SUM1315MO2 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9797.011 | uM | 14.70390 | 27.26290 | -0.9996 | -1.0000 | 1.7794 | 0.5022 | 0.9904 | 0.5004 | |
| SUM102PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9777.001 | uM | 4.61340 | 6.97730 | -0.9996 | -1.0000 | 2.6556 | 0.2639 | 0.9865 | 0.7223 | |
| MDA-MB-134-VI | HR+ | Luminal | IKK16 | IKK | NFKB | 10419.093 | uM | 6.01090 | 7.4880 | -0.9996 | -1.0000 | 5.0000 | 0.3264 | 0.9975 | 0.5719 | |
| HCC1419 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7437.095 | uM | 9.1730 | 11.91780 | -0.9996 | -1.0000 | 4.1969 | 0.3555 | 0.7786 | 0.5584 | |
| HCC1395 | TNBC | Basal B | Methylglyoxal | 13165.184 | uM | 488.01040 | 1000.00000 | -0.9995 | -0.7261 | 1.2503 | 0.4988 | 0.9358 | 0.5940 |