Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10019.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0250 | -0.1954 | 0.4626 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 5900.067 | uM | inf | inf | 0.9793 | 0.9793 | 0.0000 | -0.0189 | -0.4227 | 2.4324 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9163.001 | uM | inf | inf | -0.9994 | -0.9994 | 0.0000 | 0.4623 | 0.5005 | 0.5227 | |
| BT-20 | TNBC | Basal A | Selumetinib | MEK | MAPK | 11854.155 | uM | inf | inf | 0.9135 | 0.9135 | 0.0000 | 0.0714 | 0.3056 | 1.3396 | |
| BT-474 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 12178.144 | uM | inf | inf | 0.6802 | 0.6802 | 0.0000 | 0.1793 | -0.0043 | 0.7891 | |
| BT-20 | TNBC | Basal A | PS-1145 | IKK | NFKB | 5904.065 | uM | inf | inf | 0.7615 | 0.7615 | 0.0000 | 0.0871 | 0.5385 | 1.1681 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| 184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 7787.018 | uM | inf | inf | -0.9963 | -0.9963 | 0.0000 | 0.4831 | 0.4499 | 0.3791 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| AU565 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 10880.144 | uM | inf | inf | 0.6825 | 0.6825 | 0.0000 | 0.0829 | 0.4632 | 1.8532 | |
| 184A1 | NM | Basal | (Z)-4-Hydroxytamoxifen | ESR1 | 9047.132 | uM | inf | inf | 0.4055 | 0.4055 | 0.0000 | 0.2074 | 0.3073 | 0.6985 | ||
| BT-474 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 13125.176 | uM | inf | inf | 0.8740 | 0.8740 | 0.0000 | 0.0169 | 0.4953 | 0.8351 | |
| AU565 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 10880.144 | uM | inf | inf | 0.6567 | 0.6567 | 0.0000 | 0.2741 | 0.4357 | 1.8532 | |
| BT-483 | HR+ | Luminal | PD184352 | MEK | MAPK | 10696.146 | uM | inf | inf | 0.6829 | 0.6829 | 0.0000 | 0.1390 | 0.0199 | 0.5009 | |
| BT-549 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 5910.098 | uM | inf | inf | 0.9455 | 0.9455 | 0.0000 | -0.0163 | 0.2428 | 3.2046 | |
| BT-474 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12291.155 | uM | inf | inf | 0.8808 | 0.8808 | 0.0000 | -0.0271 | -0.2848 | 0.4532 | |
| 21MT-1 | HER2amp | - | Ribavirin | 15382.211 | uM | inf | inf | 0.9683 | 0.9683 | 0.0000 | 0.0416 | 0.0000 | 1.1714 | |||
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 5910.066 | uM | inf | inf | 1.0203 | 1.0203 | 0.0000 | -0.0416 | -10.1657 | 3.0773 | |
| BT-474 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 12178.158 | uM | inf | inf | 0.0271 | 0.0271 | 0.0000 | 0.1623 | 0.5062 | 0.7379 | |
| HCC1395 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7436.095 | uM | inf | inf | 0.9643 | 0.9643 | 0.0000 | 0.0131 | 0.0000 | 1.3597 | |
| BT-549 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 5909.085 | uM | inf | inf | 0.9298 | 0.9298 | 0.0000 | -0.0072 | 0.3654 | 3.0853 | |
| CAMA-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7805.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0217 | -0.4906 | 1.1451 | |
| BT-20 | TNBC | Basal A | PD184352 | MEK | MAPK | 10581.146 | uM | inf | inf | 0.7166 | 0.7166 | 0.0000 | 0.1279 | 0.5419 | 1.1650 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7454.095 | uM | inf | inf | 0.7171 | 0.7171 | 0.0000 | 0.1308 | 0.4162 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7455.095 | uM | inf | inf | -0.6708 | -0.6708 | 0.0000 | 0.3794 | 0.1820 | 1.8461 |