Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 7813.002 | uM | 0.00427 | 0.00565 | -0.3992 | -0.3837 | 2.0301 | 0.8129 | 0.9487 | 0.8463 | |
| HCC202 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 7844.002 | uM | 0.00427 | 0.00872 | -0.5023 | -0.4321 | 0.8713 | 0.8046 | 0.9625 | 0.5653 | |
| MCF 10A | NM | Basal B | Docetaxel | TUBB | TUBB | 12944.002 | uM | 0.00427 | 0.00446 | -0.0196 | -0.0200 | 0.9350 | 0.6124 | 0.9841 | 2.6856 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9469.011 | uM | 0.00436 | 0.00565 | -0.7427 | -0.6976 | 3.3673 | 1.3528 | 0.9958 | 1.1991 | |
| SUM52PE | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 11852.144 | uM | 0.00436 | 0.03753 | -0.3336 | -0.3874 | 0.2665 | 0.8256 | 0.8074 | 1.2876 | |
| MCF 10A | NM | Basal B | Ixabepilone | TUBB | TUBB | 7484.094 | uM | 0.00437 | 0.04204 | -0.7526 | -0.8693 | 0.4448 | 1.2063 | 0.9147 | 2.6561 | |
| SK-BR-3 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 7527.086 | uM | 0.00439 | 0.00455 | -0.0326 | -0.0168 | 0.9467 | 0.7017 | 0.9985 | 1.6742 | |
| CAMA-1 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9210.002 | uM | 0.00440 | 0.00479 | -0.2726 | -0.2659 | 5.0000 | 0.7619 | 0.9830 | 0.8958 | |
| MDA-MB-453 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 7903.042 | uM | 0.00441 | 0.00494 | -0.9524 | -0.3548 | 4.7159 | 0.9002 | 0.8859 | 1.1508 | |
| 184B5 | NM | Basal | Docetaxel | TUBB | TUBB | 9095.002 | uM | 0.00444 | 0.00218 | 0.4170 | 0.3901 | 2.1393 | 0.3930 | 0.9566 | 1.0607 | |
| UACC-812 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10580.087 | uM | 0.00444 | 0.01384 | -0.6778 | -0.6645 | 0.7435 | 1.0224 | 0.9856 | 0.8285 | |
| MDA-MB-175-VII | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 12126.158 | uM | 0.00446 | 0.01986 | -0.9994 | -1.0000 | 0.7352 | 1.3131 | 0.8929 | 0.5992 | |
| SUM159PT | TNBC | Basal B | Taxol | TUBB | TUBB | 13004.002 | uM | 0.00449 | 0.00513 | -0.1960 | -0.1508 | 1.9936 | 0.7840 | 0.9981 | 3.1387 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9402.037 | uM | 0.00449 | 0.02109 | -1.0000 | -0.9126 | 0.6718 | 1.2542 | 0.9270 | 0.3763 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9254.001 | uM | 0.00450 | 0.00522 | -1.0000 | -0.5435 | 5.0000 | 1.0717 | 0.8911 | 0.3986 | |
| EFM-192C | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15292.203 | uM | 0.00451 | 0.02673 | -0.7075 | -0.7383 | 0.5099 | 1.0406 | 0.9883 | 1.5415 | |
| EFM-192C | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15292.203 | uM | 0.00451 | 0.02673 | -0.7075 | -0.7383 | 0.5099 | 1.0406 | 0.9883 | 1.5415 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 7455.087 | uM | 0.00452 | 0.01498 | -0.7511 | -0.7799 | 0.7849 | 1.0832 | 0.9714 | 1.2897 | |
| MDA-MB-453 | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7517.095 | uM | 0.00457 | 0.00486 | -0.9304 | -0.0633 | 1.9640 | 0.6882 | 0.6096 | 1.5365 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9028.075 | uM | 0.00457 | 0.00564 | -0.9576 | -0.9350 | 5.0000 | 1.7932 | 0.9991 | 0.6011 | |
| AU565 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 7793.002 | uM | 0.00459 | 0.00690 | -0.8647 | -0.8640 | 2.4584 | 1.0405 | 0.9993 | 1.1545 | |
| HCC2185 | TNBC | Luminal | Taxol | TUBB | TUBB | 7848.002 | uM | 0.00463 | 0.00683 | -0.3379 | -0.3289 | 1.3012 | 0.8913 | 0.9640 | 0.5588 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9035.018 | uM | 0.00465 | 0.00516 | -0.4202 | -0.3390 | 5.0000 | 0.9224 | 0.9868 | 2.1555 | |
| BT-474 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 5905.086 | uM | 0.00466 | 0.01791 | -0.9740 | -0.9132 | 0.7721 | 1.1013 | 0.9957 | 0.9040 | |
| SUM1315MO2 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 10139.002 | uM | 0.00469 | 0.00782 | -0.4714 | -0.4733 | 1.3036 | 0.8187 | 0.9956 | 0.8715 |