Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Docetaxel | TUBB | TUBB | 12944.002 | uM | 0.00427 | 0.00446 | -0.0196 | -0.0200 | 0.9350 | 0.6124 | 0.9841 | 2.6856 | |
| 184A1 | NM | Basal | Docetaxel | TUBB | TUBB | 12684.002 | uM | inf | 0.00450 | 0.5376 | 0.5289 | 1.1663 | 0.2796 | 0.9570 | 1.5245 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 9844.012 | uM | 0.00867 | 0.00452 | 0.2050 | 0.2849 | 1.2949 | 0.4496 | 0.9866 | 2.2776 | |
| BT-474 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 5906.069 | uM | 0.00522 | 0.00452 | -0.0307 | 0.1007 | 1.5661 | 0.6070 | 0.9691 | 0.7682 | |
| HCC1187 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7812.002 | uM | 0.00215 | 0.00454 | -0.7983 | -0.7945 | 1.2771 | 1.0481 | 0.9866 | 1.0730 | |
| SK-BR-3 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 7527.086 | uM | 0.00439 | 0.00455 | -0.0326 | -0.0168 | 0.9467 | 0.7017 | 0.9985 | 1.6742 | |
| BT-483 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10696.144 | uM | 0.00036 | 0.00456 | -0.9999 | -0.6629 | 0.3339 | 1.1855 | 0.8042 | 0.4505 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7906.001 | uM | 0.00175 | 0.00460 | -0.6970 | -0.7979 | 0.9875 | 1.2579 | 0.8518 | 0.5685 | |
| HCC1419 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7818.068 | uM | 0.00361 | 0.00461 | -0.2968 | -0.0865 | 0.6554 | 0.8440 | 0.9116 | 0.7038 | |
| SUM159PT | TNBC | Basal B | Taxol | TUBB | TUBB | 13054.002 | uM | 0.00389 | 0.00463 | -0.1850 | -0.1586 | 1.5931 | 0.8001 | 0.9981 | 3.0574 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 14817.203 | uM | 0.00278 | 0.00465 | -0.8411 | -0.8434 | 1.9229 | 1.3693 | 0.9990 | 1.5445 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 14817.203 | uM | 0.00278 | 0.00465 | -0.8411 | -0.8434 | 1.9229 | 1.3693 | 0.9990 | 1.5445 | |
| MDA-MB-453 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 7903.002 | uM | 0.00363 | 0.00472 | -0.4272 | -0.4291 | 2.3694 | 0.8593 | 0.9957 | 1.2202 | |
| MCF12A | NM | Basal B | Trametinib | MEK | MAPK | 7873.036 | uM | 0.00567 | 0.00473 | 0.0842 | 0.0942 | 1.1532 | 0.5733 | 0.9973 | 1.9906 | |
| Hs 578T | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7862.042 | uM | 0.00207 | 0.00477 | -0.9459 | -0.7850 | 1.1301 | 1.2549 | 0.9864 | 1.2756 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 15338.203 | uM | 0.00224 | 0.00478 | -0.7351 | -0.7103 | 1.1636 | 1.2624 | 0.9965 | 1.9034 | |
| SUM229PE | TNBC | - | Bortezomib | Proteasome | Proteasome | 15338.203 | uM | 0.00224 | 0.00478 | -0.7351 | -0.7103 | 1.1636 | 1.2624 | 0.9965 | 1.9034 | |
| CAMA-1 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9210.002 | uM | 0.00440 | 0.00479 | -0.2726 | -0.2659 | 5.0000 | 0.7619 | 0.9830 | 0.8958 | |
| MDA-MB-453 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 9708.001 | uM | 0.00493 | 0.00483 | -0.0497 | 0.0123 | 1.2930 | 0.6703 | 0.9711 | 1.0142 | |
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 7488.05 | uM | 0.00327 | 0.00485 | -0.3028 | -0.2479 | 1.0200 | 0.8010 | 0.9782 | 1.3218 | |
| MDA-MB-453 | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7517.095 | uM | 0.00457 | 0.00486 | -0.9304 | -0.0633 | 1.9640 | 0.6882 | 0.6096 | 1.5365 | |
| HMT-3522 S1 | Unknown | Unknown | Docetaxel | TUBB | TUBB | 10124.002 | uM | 0.00586 | 0.00486 | 0.1013 | 0.1330 | 1.6485 | 0.5175 | 0.9891 | 2.0795 | |
| BT-474 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12291.165 | uM | 0.00084 | 0.00487 | -0.9997 | -1.0000 | 0.6233 | 1.4610 | 0.9623 | 0.5602 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10643.087 | uM | 0.00172 | 0.00488 | -1.0000 | -0.9991 | 1.0559 | 1.3640 | 0.9987 | 0.6516 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 9042.05 | uM | inf | 0.00489 | 0.5173 | 0.4903 | 0.2989 | 0.3056 | 0.8755 | 3.1161 |