Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14841.203 | uM | 0.00621 | 0.01122 | -0.9733 | -0.9729 | 1.8265 | 1.3380 | 0.9989 | 1.0330 | |
| MX1 | Unknown | Unknown | Methotrexate | DHFR | Metabolism | 7523.084 | uM | 0.01347 | 0.01123 | 0.0951 | 0.1144 | 1.4276 | 0.7084 | 0.9608 | 0.9069 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 9258.121 | uM | 0.00349 | 0.01125 | -0.9927 | -0.9212 | 0.8921 | 1.3529 | 0.9299 | 0.4800 | |
| HCC1428 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 10031.002 | uM | inf | 0.01129 | 0.5669 | 0.5754 | 1.0719 | 0.2081 | 0.9236 | 0.6483 | |
| MDA-MB-175-VII | HR+ | Luminal | Taxol | TUBB | TUBB | 7886.002 | uM | 0.01382 | 0.01129 | 0.2562 | 0.3187 | 5.0000 | 0.4089 | 0.9786 | 0.7173 | |
| SUM185PE | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 7921.042 | uM | 0.00926 | 0.01132 | -0.9855 | -0.4974 | 3.4382 | 0.9396 | 0.8930 | 0.6355 | |
| MDA-MB-453 | TNBC | Luminal | Taxol | TUBB | TUBB | 12964.002 | uM | 0.00864 | 0.01139 | -0.5617 | -0.5234 | 2.5980 | 0.9297 | 0.9952 | 0.5925 | |
| 184B5 | NM | Basal | Taxol | TUBB | TUBB | 9095.002 | uM | 0.01783 | 0.01144 | -0.0925 | 0.1784 | 0.9939 | 0.4787 | 0.9002 | 1.0607 | |
| MDA-MB-468 | TNBC | Basal A | Taxol | TUBB | TUBB | 7906.002 | uM | 0.00931 | 0.01144 | -0.8472 | -0.9052 | 4.9990 | 1.2973 | 0.7832 | 0.5736 | |
| SUM159PT | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7918.011 | uM | 0.01289 | 0.01150 | 0.1062 | 0.2169 | 4.9998 | 0.5466 | 0.9295 | 2.8897 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9913.001 | uM | 0.01022 | 0.01151 | -0.3520 | -0.4040 | 4.9494 | 0.9230 | 0.8876 | 0.3047 | |
| HCC1806 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7450.095 | uM | 0.00797 | 0.01154 | -0.8836 | -0.4702 | 1.7890 | 0.8890 | 0.9427 | 1.7844 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9278.002 | uM | 0.01066 | 0.01155 | -0.1724 | -0.1112 | 2.4854 | 0.6705 | 0.9946 | 0.3717 | |
| CAMA-1 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 5911.068 | uM | 0.01408 | 0.01156 | 0.0336 | 0.1058 | 1.2029 | 0.6546 | 0.9810 | 0.9873 | |
| 184B5 | NM | Basal | Geldanamycin | HSP90 | HSP90 | 9095.049 | uM | 0.00859 | 0.01158 | -0.7576 | -0.7255 | 2.9985 | 1.2019 | 0.9991 | 1.1202 | |
| MCF 10A | NM | Basal B | Taxol | TUBB | TUBB | 9551.002 | uM | 0.00925 | 0.01162 | -0.3111 | -0.2584 | 1.8251 | 0.7662 | 0.9937 | 2.5642 | |
| HCC1954 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 14735.203 | uM | 0.00502 | 0.01163 | -0.8105 | -0.8285 | 1.1641 | 1.2463 | 0.9910 | 2.0496 | |
| HCC1954 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 14735.203 | uM | 0.00502 | 0.01163 | -0.8105 | -0.8285 | 1.1641 | 1.2463 | 0.9910 | 2.0496 | |
| SK-BR-3 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9759.002 | uM | 0.00759 | 0.01165 | -0.7027 | -0.6563 | 1.9568 | 0.8786 | 0.9963 | 1.1336 | |
| MCF12A | NM | Basal B | Dichloroacetate | PDK | PDK | 12949.176 | uM | inf | 0.01165 | 0.7468 | 0.8256 | 1.5189 | 0.0714 | 0.7432 | 1.6075 | |
| HBL-100 | Unknown | Unknown | Vinorelbine | TUBB | TUBB | 7808.052 | uM | 0.01036 | 0.01169 | -0.8053 | -0.4166 | 5.0000 | 0.9087 | 0.9473 | 2.4842 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 10150.001 | uM | 0.00995 | 0.01171 | -0.5826 | -0.6272 | 5.0000 | 0.9813 | 0.9937 | 0.3255 | |
| MDA-MB-453 | TNBC | Luminal | Taxol | TUBB | TUBB | 9708.002 | uM | 0.00970 | 0.01172 | -0.2544 | -0.1950 | 1.7464 | 0.7160 | 0.9893 | 1.0482 | |
| HCC70 | TNBC | Basal A | Taxol | TUBB | TUBB | 7857.002 | uM | 0.00935 | 0.01182 | -0.4198 | -0.4173 | 2.5911 | 0.8656 | 0.9974 | 1.1921 | |
| HCC1954 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 9386.011 | uM | inf | 0.01184 | 0.6016 | 0.6206 | 0.8409 | 0.2743 | 0.9746 | 1.5229 |