Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | Cisplatin | DNA cross-linker | DNA cross-linker | 9095.049 | uM | inf | 193.58440 | 0.7160 | 0.7080 | 3.7384 | 0.0137 | 0.8937 | 1.1202 | |
| 184B5 | NM | Basal | Chloroquine | 12979.177 | uM | 19.64650 | 24.47430 | -1.0000 | -1.0000 | 5.0000 | 0.1512 | 0.9526 | 0.5647 | |||
| 184B5 | NM | Basal | CGC-11047 | Polyamine analogue | 9095.026 | uM | 486.65450 | 602.90190 | -0.9562 | -0.9592 | 5.0000 | 0.3089 | 0.9969 | 1.0168 | ||
| 184B5 | NM | Basal | Cetuximab | EGFR | ErbB | 9095.026 | uM | 0.04089 | 0.03186 | 0.1205 | 0.1008 | 0.9024 | 0.1873 | 0.9743 | 1.0168 | |
| 184B5 | NM | Basal | Taxol | TUBB | TUBB | 9095.002 | uM | 0.01783 | 0.01144 | -0.0925 | 0.1784 | 0.9939 | 0.4787 | 0.9002 | 1.0607 | |
| 184B5 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 9095.119 | uM | 5.77830 | 14.25320 | -0.9033 | -0.9300 | 1.1638 | 0.6853 | 0.9882 | 1.2263 | |
| 184B5 | NM | Basal | Bromopyruvic acid | Hexokinase II | Metabolism | 12979.177 | uM | 0.02740 | 0.03413 | -1.0000 | -1.0000 | 5.0000 | 1.0789 | 0.9988 | 0.5647 | |
| 184B5 | NM | Basal | Bosutinib | Src | nRTK | 12566.17 | uM | 0.54836 | 0.85384 | -0.2865 | -0.3368 | 1.1630 | 0.4044 | 0.9933 | 1.4648 | |
| 184B5 | NM | Basal | Topotecan | TOP1 | TOP | 9095.121 | uM | 0.07632 | 0.71426 | -0.8323 | -1.0000 | 0.4913 | 0.8207 | 0.9828 | 1.1992 | |
| 184B5 | NM | Basal | Bortezomib | Proteasome | Proteasome | 5896.074 | uM | 0.01517 | 0.03188 | -0.7992 | -0.7384 | 1.2208 | 1.1454 | 0.9925 | 1.4124 | |
| 184B5 | NM | Basal | Bortezomib | Proteasome | Proteasome | 5896.074 | uM | 0.01517 | 0.03188 | -0.7992 | -0.7384 | 1.2208 | 1.1454 | 0.9925 | 1.4124 | |
| 184B5 | NM | Basal | Bortezomib | Proteasome | Proteasome | 5897.074 | uM | 0.02546 | 0.03680 | -0.7949 | -0.6246 | 2.1998 | 1.0567 | 0.9711 | 1.2824 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 5897.065 | uM | 88.76350 | 175.5770 | -0.9241 | -0.9748 | 1.5858 | 0.5421 | 0.9958 | 1.2996 | |
| 184B5 | NM | Basal | Bortezomib | Proteasome | Proteasome | 5897.074 | uM | 0.02546 | 0.03680 | -0.7949 | -0.6246 | 2.1998 | 1.0567 | 0.9711 | 1.2824 | |
| 184B5 | NM | Basal | Baicalein | Lipoxygenase | Metabolism | 5897.073 | uM | 259.94010 | 173.29010 | 0.7393 | 0.4284 | 4.7935 | -0.0004 | 0.8982 | 1.2323 | |
| 184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 12566.165 | uM | 26.52190 | 125.8320 | 0.4159 | -1.0000 | 0.7056 | 0.0982 | 0.8944 | 1.7248 | |
| 184B5 | NM | Basal | AG1024 | IGF1R | RTK | 5896.066 | uM | 0.20947 | 0.20891 | -0.1513 | 0.0066 | 4.9829 | 0.4028 | 0.9686 | 1.4224 | |
| 184B5 | NM | Basal | AG1024 | IGF1R | RTK | 5897.066 | uM | 0.22173 | 0.22268 | -0.1723 | -0.0108 | 4.9920 | 0.3762 | 0.9612 | 1.2737 | |
| 184B5 | NM | Basal | Afatinib | EGFR/HER2 | ErbB | 12566.165 | uM | 0.11327 | 1.15330 | -0.8618 | -1.0000 | 0.4734 | 0.6795 | 0.9291 | 1.7248 | |
| 184B5 | NM | Basal | 5-DFUR | TYMS | TYMS | 12566.143 | uM | 303.43380 | 999.99910 | 0.1514 | -0.2734 | 0.3658 | 0.2766 | 0.9906 | 1.6413 | |
| 184B5 | NM | Basal | ZM-447439 | AURK | AURK | 12566.169 | uM | inf | 0.69572 | 0.6262 | 0.6434 | 1.3748 | 0.1369 | 0.9197 | 1.6359 | |
| 184B5 | NM | Basal | 2-deoxyglucose | 12979.177 | uM | 559.39550 | 583.2410 | -0.1158 | -0.1161 | 5.0000 | 0.2148 | 0.7107 | 0.5647 | |||
| 21MT-1 | HER2amp | - | Dichloroacetate | PDK | PDK | 13719.176 | uM | inf | inf | 0.9233 | 0.9233 | 0.0000 | 0.0596 | -0.2426 | 0.8672 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 |