Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Mebendazole | 12627.174 | uM | 0.50329 | 0.43275 | 0.0237 | 0.1162 | 1.7513 | 0.3409 | 0.9831 | 1.3419 | |||
| HCC3153 | TNBC | Basal A | Mebendazole | 13583.174 | uM | 0.16580 | 0.26708 | -0.6804 | -0.5978 | 1.6495 | 0.6918 | 0.9714 | 0.3654 | |||
| HCC3153 | TNBC | Basal A | Mebendazole | 12939.174 | uM | 0.09935 | 0.55943 | -0.8642 | -0.9370 | 0.6109 | 0.7618 | 0.9574 | 0.3466 | |||
| HCC3153 | TNBC | Basal A | Mebendazole | 13733.174 | uM | 0.22612 | 8.73650 | -0.5068 | -1.0000 | 0.3006 | 0.5298 | 0.8956 | 0.5093 | |||
| EFM-192B | HER2amp | Luminal | Ribavirin | 15288.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0002 | -0.0013 | 0.9250 | |||
| MDA-MB-415 | HR+ | Luminal | Torkinib | 15325.211 | uM | 0.00156 | 0.03995 | -0.8858 | -1.0000 | 0.3386 | 1.0873 | 0.9950 | 1.1289 | |||
| HCC3153 | TNBC | Basal A | Nelfinavir | 13583.174 | uM | 6.17610 | 7.69370 | -1.0000 | -1.0000 | 5.0000 | 0.2044 | 0.9928 | 0.3654 | |||
| HCC3153 | TNBC | Basal A | Methylglyoxal | 13603.184 | uM | 29.55980 | 192.7650 | -0.9947 | -1.0000 | 0.5859 | 0.9435 | 0.9105 | 0.7451 | |||
| MDA-MB-361 | HER2amp | Luminal | Ribavirin | 15396.211 | uM | inf | inf | 0.6490 | 0.6490 | 0.0000 | 0.0581 | 0.5449 | 0.9137 | |||
| CAMA-1 | HR+ | Luminal | Torkinib | 15348.211 | uM | 0.00176 | 0.01477 | -0.8919 | -0.9141 | 0.4883 | 1.1876 | 0.9886 | 0.7490 | |||
| SUM149PT | TNBC | Basal B | Methylglyoxal | 13123.184 | uM | 176.0360 | 328.64830 | -1.0000 | -1.0000 | 1.7598 | 0.9086 | 0.9096 | 0.6208 | |||
| SUM149PT | TNBC | Basal B | Nelfinavir | 13123.174 | uM | 8.96890 | 11.1730 | -0.9926 | -1.0000 | 4.9996 | 0.1236 | 0.9954 | 1.0408 | |||
| MDA-MB-134-VI | HR+ | Luminal | 2-deoxyglucose | 12662.177 | uM | inf | inf | 0.9676 | 0.9676 | 0.0000 | 0.0405 | 0.0000 | 1.7065 | |||
| EFM-192C | HER2amp | Luminal | Ribavirin | 15292.211 | uM | inf | inf | 0.6694 | 0.6694 | 0.0000 | 0.1738 | 0.0209 | 1.7715 | |||
| MDA-MB-453 | TNBC | Luminal | Ribavirin | 15398.211 | uM | inf | inf | 0.8982 | 0.8982 | 0.0000 | 0.0145 | 0.1417 | 1.0628 | |||
| 21MT-1 | HER2amp | - | Mebendazole | 13719.174 | uM | 31.97060 | 77.55140 | 0.0875 | -1.0000 | 1.2398 | 0.1610 | 0.8782 | 0.8124 | |||
| EFM-192B | HER2amp | Luminal | Torkinib | 15288.211 | uM | 0.00137 | 0.00325 | -0.6816 | -0.5670 | 0.8789 | 1.1523 | 0.9810 | 0.9250 | |||
| EFM-192B | HER2amp | Luminal | Torkinib | 15387.211 | uM | 0.00291 | 0.01240 | -0.6500 | -0.6119 | 0.5521 | 1.0170 | 0.9955 | 1.2404 | |||
| 21MT-1 | HER2amp | - | Methylglyoxal | 13719.184 | uM | 680.32080 | 999.99990 | -0.9954 | -0.9645 | 2.7899 | 0.6345 | 0.9961 | 0.7600 | |||
| SUM1315MO2 | TNBC | Basal B | Ribavirin | 15401.211 | uM | inf | inf | 0.9740 | 0.9740 | 0.0000 | 0.0925 | 0.0630 | 0.4079 | |||
| HCC3153 | TNBC | Basal A | Nelfinavir | 12939.174 | uM | 2.09890 | 5.54180 | -0.9996 | -1.0000 | 1.1315 | 0.4041 | 0.9209 | 0.3466 | |||
| HCC3153 | TNBC | Basal A | Nelfinavir | 13733.174 | uM | 6.79860 | 9.17240 | -0.9963 | -1.0000 | 3.6683 | 0.3309 | 0.9153 | 0.5093 | |||
| LY2 | HR+ | Luminal | Methylglyoxal | 13639.184 | uM | inf | inf | -0.8274 | -0.8274 | 0.0000 | 0.3747 | 0.4895 | 1.5976 |