Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | 5-FU | TYMS | TYMS | 7864.017 | uM | 56.13570 | 165.52520 | -0.5570 | -0.6452 | 0.7664 | 0.6230 | 0.9857 | 1.6561 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10693.143 | uM | 32.71250 | 294.6010 | -0.7181 | -1.0000 | 0.4999 | 0.5168 | 0.9904 | 0.7509 | |
| HCC70 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10873.143 | uM | 200.95550 | 1000.00000 | -0.1837 | -0.6154 | 0.5000 | 0.2961 | 0.9812 | 1.2785 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 10996.143 | uM | 124.03170 | 741.86030 | -0.5992 | -1.0000 | 0.6142 | 0.4500 | 0.8811 | 0.3034 | |
| HCC70 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 12400.143 | uM | 198.37950 | 1000.00000 | -0.1208 | -0.5081 | 0.4335 | 0.2997 | 0.9432 | 1.3002 | |
| HCC1428 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 11936.143 | uM | 120.84610 | 672.77120 | -0.8036 | -1.0000 | 0.6399 | 0.4259 | 0.9363 | 0.7979 | |
| HCC1428 | HR+ | Luminal | 5-FU | TYMS | TYMS | 9294.017 | uM | 6.17330 | 16.50340 | -0.7904 | -0.7842 | 0.9593 | 1.0530 | 0.8821 | 0.8160 | |
| HCC70 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7857.017 | uM | 64.75590 | 188.94070 | -0.9642 | -1.0000 | 1.0260 | 0.8100 | 0.9595 | 1.1840 | |
| Hs 578T | TNBC | Basal B | 5-FU | TYMS | TYMS | 7862.017 | uM | 19.90020 | 39.44990 | -0.6175 | -0.5998 | 1.1520 | 0.7981 | 0.9882 | 1.3198 | |
| HCC38 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9453.017 | uM | 204.98770 | 867.09230 | -0.5306 | -0.7483 | 0.6344 | 0.4287 | 0.9866 | 1.2279 | |
| 184B5 | NM | Basal | 5-DFUR | TYMS | TYMS | 12566.143 | uM | 303.43380 | 999.99910 | 0.1514 | -0.2734 | 0.3658 | 0.2766 | 0.9906 | 1.6413 | |
| BT-549 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7804.017 | uM | 634.7870 | 891.18150 | 0.0616 | -0.1015 | 0.5450 | 0.2855 | 0.9962 | 2.5963 | |
| HCC38 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9469.131 | uM | 492.70010 | 1000.00000 | -0.6025 | -0.6339 | 1.1567 | 0.3652 | 0.9907 | 1.0627 | |
| BT-549 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 12305.143 | uM | 561.79720 | 545.14620 | 0.1728 | 0.0108 | 0.7280 | 0.2041 | 0.9874 | 2.9115 | |
| BT-549 | TNBC | Basal B | 5-FU | TYMS | TYMS | 10261.131 | uM | 215.57540 | 290.46960 | -0.0136 | -0.0848 | 0.5253 | 0.3560 | 0.9881 | 2.3992 | |
| BT-549 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7803.017 | uM | 238.0370 | 263.75510 | 0.0274 | -0.0295 | 0.5595 | 0.3494 | 0.9927 | 2.9572 | |
| HCC38 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 10578.143 | uM | 308.37710 | 997.79880 | -0.0975 | -0.5173 | 0.6049 | 0.2789 | 0.9834 | 1.6935 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 9118.017 | uM | 78.35630 | 305.35030 | -0.9327 | -1.0000 | 0.8077 | 0.6926 | 0.9801 | 1.0401 | |
| HCC38 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 11850.143 | uM | 173.320 | 240.01390 | 0.0956 | -0.0902 | 0.5094 | 0.2951 | 0.9876 | 2.1044 | |
| HCC38 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7854.017 | uM | 95.97870 | 1000.00000 | -0.5133 | -0.8772 | 0.4323 | 0.5201 | 0.9440 | 1.3102 | |
| HCC3153 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10577.143 | uM | 971.46680 | 1000.00000 | 0.0340 | -0.0227 | 1.5355 | 0.1782 | 0.9329 | 0.9750 | |
| HCC3153 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10937.143 | uM | 558.30230 | 999.99960 | -0.0412 | -0.3041 | 0.8151 | 0.2210 | 0.9770 | 1.3133 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9035.017 | uM | 234.20810 | 255.89090 | 0.0352 | -0.0320 | 0.6997 | 0.3489 | 0.9930 | 2.2905 | |
| HCC1937 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7834.13 | uM | 453.5720 | 570.59710 | 0.0562 | -0.0678 | 0.5542 | 0.3087 | 0.9979 | 1.9535 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 9047.017 | uM | 48.1950 | 95.9710 | -0.8459 | -0.8556 | 1.4480 | 0.8094 | 0.9747 | 0.8440 |