Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5909.095 | uM | inf | 21.08430 | 0.9127 | 0.9359 | 5.0000 | 0.0085 | 0.6083 | 2.7716 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 10996.143 | uM | 124.03170 | 741.86030 | -0.5992 | -1.0000 | 0.6142 | 0.4500 | 0.8811 | 0.3034 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 12192.143 | uM | 875.95260 | 1000.00000 | -0.0499 | -0.1056 | 1.4465 | 0.1455 | 0.9340 | 0.5995 | |
| HCC1395 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7814.017 | uM | 306.00360 | 1000.00000 | -0.5095 | -0.6608 | 0.7113 | 0.3922 | 0.9860 | 0.8254 | |
| 184A1 | NM | Basal | 5-FU | TYMS | TYMS | 9047.017 | uM | 48.1950 | 95.9710 | -0.8459 | -0.8556 | 1.4480 | 0.8094 | 0.9747 | 0.8440 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7450.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.7844 | |
| HCC2185 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7462.095 | uM | inf | inf | 0.6298 | 0.6298 | 0.0000 | 0.0764 | 0.3441 | 0.3840 | |
| HBL-100 | Unknown | Unknown | 5-FU | TYMS | TYMS | 7807.017 | uM | 112.83770 | 154.79750 | -0.0609 | -0.0980 | 0.5660 | 0.4078 | 0.9916 | 2.2007 | |
| HCC1395 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7436.095 | uM | inf | inf | 0.9643 | 0.9643 | 0.0000 | 0.0131 | 0.0000 | 1.3597 | |
| HCC3153 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10937.143 | uM | 558.30230 | 999.99960 | -0.0412 | -0.3041 | 0.8151 | 0.2210 | 0.9770 | 1.3133 | |
| HCC1395 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7435.095 | uM | inf | inf | 0.8669 | 0.8669 | 0.0000 | 0.0762 | -0.0489 | 0.8762 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7466.095 | uM | inf | inf | 1.0039 | 1.0039 | 0.0000 | -0.0104 | -0.0877 | 0.8699 | |
| HCC38 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 11850.143 | uM | 173.320 | 240.01390 | 0.0956 | -0.0902 | 0.5094 | 0.2951 | 0.9876 | 2.1044 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9035.017 | uM | 234.20810 | 255.89090 | 0.0352 | -0.0320 | 0.6997 | 0.3489 | 0.9930 | 2.2905 | |
| HCC38 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9453.017 | uM | 204.98770 | 867.09230 | -0.5306 | -0.7483 | 0.6344 | 0.4287 | 0.9866 | 1.2279 | |
| HCC38 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9469.131 | uM | 492.70010 | 1000.00000 | -0.6025 | -0.6339 | 1.1567 | 0.3652 | 0.9907 | 1.0627 | |
| 184B5 | NM | Basal | 5-DFUR | TYMS | TYMS | 12566.143 | uM | 303.43380 | 999.99910 | 0.1514 | -0.2734 | 0.3658 | 0.2766 | 0.9906 | 1.6413 | |
| BT-474 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5906.095 | uM | inf | inf | 1.0129 | 1.0129 | 0.0000 | 0.0481 | 0.0000 | 0.6731 | |
| CAMA-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12070.143 | uM | 180.68920 | 330.87140 | -0.0282 | -0.2049 | 0.5677 | 0.2807 | 0.9638 | 0.9561 | |
| CAMA-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10755.143 | uM | 8.13980 | 33.83090 | 0.0811 | -0.1496 | 0.1837 | 0.5019 | 0.6967 | 0.9034 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7820.017 | uM | 127.9330 | 620.18530 | -0.7617 | -0.9506 | 0.6748 | 0.5583 | 0.9859 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7821.017 | uM | 232.84290 | 534.85860 | -0.8970 | -0.8996 | 1.2377 | 0.4969 | 0.9956 | 0.3792 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 9118.017 | uM | 78.35630 | 305.35030 | -0.9327 | -1.0000 | 0.8077 | 0.6926 | 0.9801 | 1.0401 | |
| UACC-812 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7547.095 | uM | inf | inf | 0.4710 | 0.4710 | 0.0000 | 0.2660 | 0.1131 | 1.0102 | |
| UACC-812 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7926.017 | uM | 96.4740 | 365.57480 | -0.8709 | -0.9538 | 0.8012 | 0.6208 | 0.9943 | 0.8896 |