Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 7848.017 | uM | 0.17714 | 0.50367 | -1.0000 | -1.0000 | 1.0513 | 0.9005 | 0.9933 | 0.3225 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 9044.065 | uM | 35.57120 | 53.06090 | -1.0000 | -1.0000 | 2.7472 | 0.7056 | 0.9961 | 0.5944 | |
| SUM1315MO2 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9797.006 | uM | 0.00425 | 0.00528 | -1.0000 | -0.9693 | 4.9995 | 1.7533 | 0.9968 | 0.4196 | |
| SUM149PT | TNBC | Basal B | Methylglyoxal | 13123.184 | uM | 176.0360 | 328.64830 | -1.0000 | -1.0000 | 1.7598 | 0.9086 | 0.9096 | 0.6208 | |||
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14176.189 | uM | 0.07247 | 0.0870 | -1.0000 | -0.7475 | 5.0000 | 0.9511 | 0.8952 | 0.4285 | |
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14176.189 | uM | 0.07247 | 0.0870 | -1.0000 | -0.7475 | 5.0000 | 0.9511 | 0.8952 | 0.4285 | |
| HCC70 | TNBC | Basal A | Nelfinavir | 12714.174 | uM | 8.95410 | 11.15450 | -1.0000 | -1.0000 | 5.0000 | 0.3201 | 0.8734 | 0.3306 | |||
| MDA-MB-361 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12379.165 | uM | 0.00707 | 0.02452 | -1.0000 | -0.9566 | 0.8596 | 1.1784 | 0.9915 | 0.3550 | |
| HCC2185 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 7462.065 | uM | 37.55690 | 65.95580 | -1.0000 | -1.0000 | 1.9509 | 0.9428 | 0.9838 | 0.3950 | |
| MX1 | Unknown | Unknown | MG-132 | Proteasome | Proteasome | 10644.145 | uM | 0.04734 | 0.07256 | -1.0000 | -1.0000 | 2.5730 | 1.0527 | 0.9991 | 0.4300 | |
| MDA-MB-361 | HER2amp | Luminal | NU6102 | CDK1/2 | CDK | 12379.147 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 0.2178 | 0.2648 | 0.3192 | |
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14257.189 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 0.9813 | 0.4558 | 0.3775 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 10996.143 | uM | 442.73320 | 1000.00000 | -1.0000 | -1.0000 | 1.3483 | 0.4840 | 0.9488 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 7462.065 | uM | 22.21550 | 27.67390 | -1.0000 | -0.9998 | 5.0000 | 0.8649 | 0.9889 | 0.3950 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 7477.066 | uM | 5.95670 | 7.42050 | -1.0000 | -1.0000 | 5.0000 | 0.4047 | 0.9709 | 0.3409 | |
| MDA-MB-361 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 9648.017 | uM | 0.17877 | 0.21867 | -1.0000 | -0.8691 | 5.0000 | 0.9654 | 0.9842 | 0.5727 | |
| HCC1937 | TNBC | Basal A | Methylglyoxal | 13177.184 | uM | 504.29230 | 687.61710 | -1.0000 | -1.0000 | 3.5430 | 0.6770 | 0.9873 | 0.3394 | |||
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10643.138 | uM | 4.41480 | 12.29050 | -1.0000 | -1.0000 | 1.0730 | 0.3544 | 0.9705 | 0.4981 | |
| HCC3153 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 13583.174 | uM | 0.07381 | 0.07938 | -1.0000 | -0.2193 | 5.0000 | 0.5952 | 0.7724 | 0.3654 | |
| BT-20 | TNBC | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14230.189 | uM | 0.27401 | 0.47494 | -1.0000 | -1.0000 | 1.9974 | 0.7978 | 0.9974 | 0.4635 | |
| HCC2185 | TNBC | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9421.021 | uM | 13.02370 | 26.1650 | -1.0000 | -1.0000 | 1.5747 | 0.5987 | 0.9904 | 0.3726 | |
| MDA-MB-361 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12379.165 | uM | 0.96508 | 2.0870 | -1.0000 | -1.0000 | 1.4244 | 0.6024 | 0.9805 | 0.3550 | |
| MDA-MB-361 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 12989.174 | uM | 0.06115 | 0.07443 | -1.0000 | -0.4869 | 3.4592 | 0.7829 | 0.8122 | 0.7084 | |
| HCC1187 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7811.044 | uM | 11.65150 | 16.05880 | -1.0000 | -0.9995 | 3.4233 | 0.3459 | 0.9975 | 0.3073 | ||
| HCC1187 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7811.04 | uM | 1.04690 | 1.38930 | -1.0000 | -0.9258 | 3.7023 | 0.7792 | 0.8482 | 0.3921 |