Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9759.006 | uM | 0.01154 | 0.01323 | -0.9273 | -0.4937 | 4.9999 | 1.1745 | 0.8807 | 1.2714 | |
| HCC2185 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 7849.04 | uM | 0.01717 | 0.02311 | -0.8205 | -0.7965 | 3.2059 | 1.1738 | 0.9991 | 0.5448 | |
| BT-474 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9158.049 | uM | 0.00737 | 0.00871 | -0.8389 | -0.6523 | 5.0000 | 1.1719 | 0.9370 | 0.4082 | |
| BT-20 | TNBC | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14116.189 | uM | 0.11656 | 0.17087 | -0.9997 | -1.0000 | 2.8722 | 1.1707 | 0.7408 | 0.5416 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7905.001 | uM | 0.0120 | 0.01548 | -0.8909 | -0.9012 | 4.0535 | 1.1707 | 0.9541 | 0.7433 | |
| Hs 578T | TNBC | Basal B | Omipalisib | PI3K | PI3K | 7471.087 | uM | 0.00095 | 0.01694 | -0.9408 | -1.0000 | 0.3813 | 1.1700 | 0.910 | 0.5895 | |
| HCC1187 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 9244.002 | uM | 0.00175 | 0.00410 | -0.9956 | -0.9809 | 1.2760 | 1.1697 | 0.9846 | 0.5206 | |
| MX1 | Unknown | Unknown | Omipalisib | PI3K | PI3K | 10644.087 | uM | 0.00548 | 0.01873 | -0.9983 | -0.9866 | 0.8862 | 1.1685 | 0.9633 | 0.5708 | |
| MDA-MB-157 | TNBC | Basal B | Taxol | TUBB | TUBB | 10093.002 | uM | 0.00477 | 0.00766 | -0.8190 | -0.7899 | 2.0005 | 1.1679 | 0.9965 | 0.9296 | |
| HCC1187 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7811.002 | uM | 0.00284 | 0.00560 | -0.9883 | -0.9948 | 1.6129 | 1.1674 | 0.9996 | 0.4929 | |
| MDA-MB-361 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9648.011 | uM | 0.00368 | 0.00618 | -0.5201 | -0.5019 | 1.3387 | 1.1674 | 0.9957 | 0.6920 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 5900.074 | uM | 0.02550 | 0.03474 | -0.7420 | -0.7576 | 2.9828 | 1.1668 | 0.9988 | 2.4189 | |
| AU565 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 5900.074 | uM | 0.02550 | 0.03474 | -0.7420 | -0.7576 | 2.9828 | 1.1668 | 0.9988 | 2.4189 | |
| SUM52PE | HR+ | Luminal | AG1478 | EGFR | ErbB | 7923.016 | uM | inf | inf | -0.8836 | -0.8836 | 0.0000 | 1.1667 | 0.3996 | 0.6280 | |
| AU565 | HER2amp | Luminal | Taxol | TUBB | TUBB | 7793.002 | uM | 0.00772 | 0.01042 | -0.8865 | -0.8641 | 3.3455 | 1.1660 | 0.9995 | 1.1545 | |
| HCC1428 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7442.085 | uM | 0.00643 | 0.01886 | -0.9964 | -1.0000 | 1.0202 | 1.1658 | 0.9946 | 0.8237 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9163.037 | uM | 0.02296 | 0.02797 | -0.9651 | -0.8419 | 4.9994 | 1.1656 | 0.9949 | 0.5258 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7906.001 | uM | 0.01404 | 0.01736 | -0.9808 | -0.9456 | 5.0000 | 1.1656 | 0.9648 | 0.5685 | |
| HCC1187 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 12696.002 | uM | 0.00173 | 0.00493 | -0.9723 | -0.9900 | 1.0427 | 1.1646 | 0.9945 | 0.7184 | |
| HCC38 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 10418.095 | uM | 0.00180 | 0.00302 | -0.9979 | -0.6317 | 1.5781 | 1.1635 | 0.950 | 1.1425 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9933.012 | uM | 0.01405 | 0.04626 | -0.9704 | -0.9475 | 0.8922 | 1.1632 | 0.9798 | 0.4114 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 7491.078 | uM | 0.00884 | 0.07326 | -0.9966 | -1.0000 | 0.5196 | 1.1630 | 0.9783 | 0.7238 | |
| BT-474 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12056.158 | uM | 0.00506 | 0.01885 | -0.9829 | -0.8526 | 0.7565 | 1.1618 | 0.9747 | 0.9929 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7477.084 | uM | 0.00794 | 0.01777 | -0.9982 | -1.0000 | 1.3641 | 1.1602 | 0.9984 | 0.9476 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7905.012 | uM | 0.01689 | 0.02851 | -0.7388 | -0.7974 | 1.8227 | 1.1600 | 0.9843 | 0.7027 |